Prostaglandin And Other Eikosanoids Flashcards
Cyclooxygenase ____: Found in many tissues and are active in many physiologic processes
1
Cyclooxygenase ____: Found primarily in inflammatory cells Major role in tissue injury Synthesis of prostacyclin and prostaglandin
2
These constitute the Slow-reacting substances of anaphylaxis
Leukotriene C4, D4
Prostaglandin that is protective of gastric mucosa and keeps PDA patent
E1
Prostaglandin that increases uterine tone, also maintains PDA
E2
Pulmonary prostaglandin
I2
Prostaglandin that decreases IOP, increases uterine tone
F2alpha
Prostaglandin for Platelet Aggregation
TXA2
Causes increased HCO3 and mucus secretion in the stomach, also causes uterine contraction Drug for PUD, prevention of NSAID induced gastric mucosal injury SE: miscarriage, Moebius sequence Drug, Class
Misoprostol, Prostaglandin E1 analog (Gemeprost)
Causes vascular smooth muscle relaxation and vasodilation Drug for maintenance of PDA, erectile dysfunction SE: priapism, light headedness Drug, Class
Alprostadil, Prostaglandin E1 analog
Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle Drug for induction of labor, cervical ripening, abortifacient SE: cramps, fetal trauma Drug, Class
Dinoprostone, Prostaglandin E2 analog (Sulprostone)
Activates FP receptors For control of postpartum hemorrhage, abortifacient SE: Vomiting, diarrhea, transient bronchoconstriction Drug, Class
Carboprost, Prostaglandin F2alpha analog (Bimatoprost, Travoprost, Unioprostone)
Causes vasodilation, reduces platelet aggregation Drug for pulmonary HPN, reduces platelet aggregation in dialysis machines SE: hypotension, flushing, headache
EPOprostenol (as in Erythropoeitin) (Beraprost, Iloprost, Treprostinil)
Increases outflow of aqueous humor Reduces IOP Drug for glaucoma Alters iris color, causing permanent eye color change
Latanoprost, Prostaglandin F2alpha analog (Bimatoprost, Travoprost, Unoprostone)
Eikosanoids are produced from?
Arachidonic acid
