Drugs For Anemia And Hematopoeitic Growth Factors

Question 1

Deficiency in _______ or _______ can cause megaloblastic anemia

Answer 1

Vitamin B12 or folic acid

Question 2

Heavy metal chelator
Drug for acute Iron Toxicity
SE: ARDS, neurotoxicity, susceptibility to infections

Answer 2

Deferoxamine, Chelator

Question 3

Tx for IDA

Answer 3

Ferrous Sulfate

Question 4

Most common type of megaloblastic anemia

Answer 4

Pernicious anemia (defect in IF synthesis)

Question 5

Acute overdose of ferrous sulfate causes

Answer 5

Necrotizing gastroenteritis

Question 6

Drug with most amount of iron concentration

Answer 6

Ferrous Fumarate

Question 7

Chronic iron overload can cause

Answer 7

Hemochromatosis

Question 8

Triad of hemochromatosis

Occurs in pxs with abnormal iron absorption or frequent transfusions

Answer 8

Cirrhosis
DM
Hyperpigmentation

Question 9

Tx for hemochromatosis

Answer 9

Phlebotomy
Chronic Deferoxamine (IV) or Deferasirox (IM)

Question 10

Co factor in transfer of 1 carbon units, necessary step for DNA synthesis

Drug?

Answer 10

Vit B12

Question 11

____________ deficiency causes neurologic effects

Answer 11

Vit B12

NOT FOLIC ACID

Question 12

Neurologic effect of Vit B12 deficiency

Answer 12

Ataxic gait
Impaired position and vibratory sense
Spasticity

Question 13

__________ deficiency: RBC production slows down

Answer 13

Vit B12

Question 14

Hematoietic Growth Factor
Cofactor required to convert homocysteine to methionine, and metabolize methylmalonyl CoA
Drug for Vit B12 deficiency, megaloblastic anemia

Answer 14

Cyanocobalamin

Hydroxocobalamin

Question 15

Required for normal DNA synthesis
Deficiency can cause NTD (Spina Bifida)

Drug?

Answer 15

Folic Acid

Question 16

Area of the GIT where Folic Acid is absorbed

Answer 16

Proximal jejunum

Question 17

Hematopoietic Growth Factor
Essential donor of methyl groups for synthesis of AA, purines and deoxynucleotide
Drug for megaloblastic anemia, prevention of coronary artery disease, prevention of NTD

Answer 17

Folic Acid (synthetic)
Folate (natural)
(Folacin, Folinic Acid)

Question 18

Agonist of Erythropoeitin receptors expressed by red cell progenitors
Drug associated with CKD
SE: pure red cell aplasia
HgB should be maintained <12g/dl
Prohibited as performance enhancing drug

Answer 18

Epoetin Alfa

LAHAT NG MAY EPO

Question 19

Myeloid growth factor
Accelerates neutrophil recovery and reduces incidence of infection
Drug for neutropenia associated with chemotherapy
SE: arthralgia, fever, edema

Answer 19

Granulocyte Colony Stimulating Factor (G-CSF)

LAHAT NG MAY -STIM

Question 20

Increased or Decreased in Iron Deficiency Anemia?
Iron
Ferritin
TIBC

Answer 20

Decreased
Decreased
Increased

Question 21

Treatment of neutropenia and agranulocytosis

Answer 21

Filgrastim

Question 22

Megakaryocyte growth factor
Activate IL-11 receptors
Drug for prevention of chemotherapy induced thrombocytopenia
SE: pleural effusion, transient atrial arrhythmia

Answer 22

Oprelvekin

Thrombopoietin