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Pharmacology by THer > Antipsychotic Agents and Lithium > Flashcards

Antipsychotic Agents and Lithium Flashcards

1
Q

Typical (Classical) Antipsychotics

A

Phenothiazines (Chlorpromazine, Thioridazine, Fluphenazine)
Thioxanthenes (Thiothixene)
Butyrophenones (Haloperidol)

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2
Q

Atypical Antipsychotics

A

Heterocyclics (Clozapine, Loxapine, Olanzapine, Risperidone, Quetiapine, Ziprazidone, Aripiprazole)

LAHAT NG MAY -PINE at -DONE

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3
Q

_____ Potency:

fewer extrapyramidal effects, more H1, Alpha1 and muscarinic blocking effects

A

Low

i.e. Chlorpromazine, Thioridazine, Mesoridazine

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4
Q

_____ Potency:

more extrapyramidal effects, less H1, Alpha1 and muscarinic blocking effects

A

High

i.e. Haloperidol, Fluphenazine, Droperidol

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5
Q

These Dopamine ___ receptors are the target of older antipsychotics

A

D2 receptors in the caudate putamen, nucleus accumbens, cerebral cortex and hypothalamus

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6
Q

Identify the Dopaminergic Tract:

Regulates mentation and mood

A

Mesocorticcal - Mesolimbic

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7
Q

Identify the Dopaminergic Tract:

Extrapyramidal function

A

Nigrostriatal

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8
Q

Identify the Dopaminergic Tract:

Control of PRL release

A

Tuberoinfundibular

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9
Q

Identify the Dopaminergic Tract:

Eating behavior

A

Medullary-Periventricular

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10
Q

Identify the Dopaminergic Tract:

Anticipatory motivational phase of copulatory behavior

A

Incertohypothalamic

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11
Q

Antipsychotic that decreases incidence of suicide

A

Clozapine

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12
Q

Antipsychotic Toxicities

A 
Constipation, dry mouth, loss of accomodation
Orthostatic hypotension, impotence
Toxic-confusional state
Weight gain
Hyperprolactinemia
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13
Q

Hallucinogenic Receptors

A

5HT2A/2C

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14
Q

Antipsychotics that can improve + symptoms but not - symptoms

A

Typical/Classical

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15
Q

Antipsychotics that can improve both + and - symptoms

A

Atypical

PERO SOBRANG MAHAL

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16
Q

Tx for Acute Dystonia

A

Diphenhydramine

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17
Q

Tx for Parkinsonism

A

Benztropine

18
Q

Tx for Rabbit Syndrome

A

Benztropine

19
Q

Tx for Tardive Dyskinesia

A

None

20
Q

Tx for Akathisia

A

Diphenhydramine

21
Q

Tx for Neuroleptic Malignant Syndrome

A

Withdraw drug, Dantrolene

22
Q

Typical Antipsychotics

Blocks D2 receptors»5HT2

A

Chlorpromazine
Thioridazine
Haloperidol

LAHAT NG -ZINE

23
Q

Atypical Antipsychotics

Blocks 5HT2»D2

A 
Clozapine
Olanzapine
Quetiapine
Risperidone
Ziprazidone
Aripiprazole

LAHAT NG -PINE at -DONE

24
Q

Sx of Neurleptic Malignant Syndrome

FEVER

A 
Fever
Encephalopathy
Vitals Unstable
Elevated CPK
Rigidity
25
Q

Prototype typical antipsychotic
SE: CORNEAL AND LENS Deposits, failure of ejaculation, marked sedation, neuroleptic malignant syndrome, contact dermatitis

A

Chlorpromazine

Phenothiazine

26
Q

Typical antipsychotic for anti-emesis
SE: RETINAL deposits, failure of ejaculation, cardiotoxicity (arrhythmia)
Strongest AUTONOMIC EFFECTS

A

Thioridazine

Phenothiazine

27
Q

Only antipsychotic with Fatal Overdose

A

Thioridazine

Phenothiazine

28
Q 
Typical antipsychotic 
Drug for Huntington, Tourette's
SE: EPS (major), Neuroleptic Malignant Syndrome
Weakest AUTONOMIC EFFECTS
Least sedating
A

Haloperidol

Butyrophenone

29
Q

Prototype atypical antipsychotic
Drug for refractory schizophrenia, suicidal
SE: AGRANULOCYTOSIS, weight gain, hyperglycemia, hyperlipidemia, myocarditis, seizures, ileus, hypersalivation

A

Clozapine

30
Q

Atypical antipsychotic for Bipolar disorder, anorexia nervosa, depression
SE: weight gain, hyperglycemia, hyperlipidemia

A

Olanzapine

31
Q

Atypical antipsychotic

SE: Somnolence, Fatigue, Sleep paralysis, Hypnagogic hallucinations, cataracts, priapism

A

Quetiapine

32
Q

Atypical antipsychotic for intractable hiccups, Tourette’s syndrome
SE: Hyperprolactinemia, Photosensitivity
Only antipsychotic approved for schizophrenia in the youth

A

Risperidone

33
Q

Atypical antipsychotic
SE: Postural hypotension, QT prolongation (Torsades)
Little or not tendency to cause hyperglycemia, hyperprolactinemia or weight gain
Increased mortality in elderly patients with dementia-related psychosis

A

Ziprasidone

PUSO

34
Q 
Atypical antipsychotic
Least sedating atypical antipsychotic
no atropine like effects
Little or not tendency to cause hyperglycemia, hyperprolactinemia or weight gain
Very good safety profile
A

Aripiprazole

35
Q

Sx of Neuroleptic Malignant Syndrome

A 
Fever
Encephalopathy
Vitals Unstable
Elevated CPK
Rigidity
36
Q

Tx of Bipolar disorder
Used with antidepressants during maintenance therapy
Slow onset of action
Protective versus suicide and self-harm

A

Lithium

37
Q

Mood stabilizer that decreases cAMP, Inhibits Inositol1phosphate
SE: Thyroid enlargement, Nephrogenic DI, Edema, Leukocytosis, Teratogen, Ebstein’s Anomaly, Bradycardia
Contraindicated in Sick Sinus Syndrome

A

Lithium

38
Q

Tx of Lithium overdose

A

Hemodialysis

39
Q

Threshold for Lithium Toxicity

A

2 mEq/L

40
Q

Sx of Lithium Overdose

A

Neuromuscular excitability, tremors, twitching, agitation, weakness, ataxia, leukocytosis, bradycardia, hypotension

Pharmacology by THer (31 decks)

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