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Pharmacology by THer > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Tricyclic Antidepressants

A

Imipramine

Amitryptyline

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2
Q

SSRIs

A

Fluoxetine
Escitalopram
Paroxetine
Sertraline

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3
Q

SNRIs

A

Duloxetine

Venlafaxine

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4
Q

Serotonin 5HT2 Antagonists

A

Nafazodone

Trazodone

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5
Q

Heterocyclic Antidepressants

A

Amoxapine
Bupropion
Maprotiline
Mirtazapine

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6
Q

TCA
Blocks NE and 5HT transporters
Backup drug for MDD
Additive depression of the CNS with other central depressants

Drug?

A

Imipramine

Clomipramine, Desipramine, AMITRYPTILINE, Nortryptiline

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7
Q

TCA:
Toxic Dose: _____
Lethal Dose: _____

A

7mg/kg (7 tabs Imipramine 75mg)

15mg/kg (14 tabs Imipramine 75mg)

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8
Q

3 Cs of TCA Overdose

A

Cardiotoxicity
Coma
Convulsions

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9
Q

Tx of TCA Overdose

A 
Supportive Therapy (Fluid resuscitation, activated charcoal, benzodiazepines)
Bicarbonate to reverse cardiotoxicity
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10
Q

SSRI
First line for MDD
SE: Erectile dysfunction, withdrawal syndrome
Serotonin Syndrome when used with MAOIs

A

Fluoxetine

Paroxetine, Citalopram, Escitalopram, Sertraline, Fluvoxamine

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11
Q

SSRIs that are CYP450 inhibitors

A

Fluoxetine

Fluvoxamine

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12
Q

Drugs that cause erectile dysfunction

A 
SORE PEnis Still Fucks Hard
SSRIs
Opiates
Risperidone
Ethanol
Propranolol
Estrogen
Spironolactone
Finasteride
Hydrochlorothiazide
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13
Q

Life-threatening syndrome characterized by severe muscle rigidity, myoclonus, hyperthermia, cardiovascular instability, and marked CNS stimulatory effects including seizures

A

Serotonin Syndrome

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14
Q

SNRI
Alternative to SSRIs for MDD
SE: Hypertension, Hepatotoxicity, Withdrawal

A

Venlafaxine

Duloxetine, Desvenlafaxine

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15
Q

SNRI that is a CYP450 inhibitor

A

Venlafaxine

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16
Q

Serotonin antagonist that blocks 5HT2 receptors
SE: orthostatic hypotension, priapism, hepatotoxicity
Can cause arrhythmia in pxs with pre-existing cardiac disease

A

Trazodone

Nefazodone

17
Q

Drugs to cause Priapism

A 
Tigas Penis QU AyaW Bumaba
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion
18
Q

Tetracyclic antidepressants
Strong epinephrine reuptake inhibitor, weak serotonin reuptake inhibitor, Blocks Dopamine D2
SE: Akathisia, Parkinsonism, Amenorrhea-Galactorrhea Syndrome, Seizures, Cardiotoxicity
Lowers Seizure Threshold

A

Amoxapine

19
Q

Increases amine release from nerve endings by antagonism of presynaptic alpha2 adrenoceptors, blocks 5HT2 receptors
Drug for major depression, appetite stimulation
SE: Weight gain, marked sedation

A

Mirtazapine

20
Q 
TCA
Inhibits neuronal reuptake of Dopamine
Drug for smoking cessation
SE: Weight loss, seizures, priapism
Lowers seizure threshold
A

Bupropion

21
Q

MAOI
Inhibits monoamine oxidase type A and type B
Drug for Parkinsons
SE: Insomnia, Orthostatic hypotension
Hypertensive crisis when taken with Tyramine (sympathomimetic in cheese/wine)
Serotonin syndrome when taken with SSRIs

A

Phenelzine

Tranylcypromine, Selegiline

22
Q

Sx of Serotonin Syndrome

A 
FAT CHD (KID)
Fever
Agitation
Tremor
Clonus
Hyperreflexia
Diaphoresis
23
Q

Precipitating drug for Malignant Hyperthermia

A

Succinylcholine

24
Q

Onset/Pathophysio of Malignant Hyperthermia

A

Within Minutes

Massive Ca release from SR

25
Q

First Line Tx for Malignant Hyperthermia

A

Dantrolene

26
Q

Participating drug for Serotonin Syndrome

MMMSST

A 
MAOI
Meperidine
MDMA
SSRIs
St. John's Wort
TCA
27
Q

Onset/Pathophysio of Serotonin Syndrome

A

Within Hours

Excess Serotonin

28
Q

First line Tx for Serotonin Syndrome

A

Sedation
Paralysis
Intubation
Ventilation

29
Q

Precipitating drug for Neuroleptic Malignant Syndrome

A

Antipsychotics

30
Q

Onset and Pathophysio of Neuroleptic Malignant Syndrome

A

1-3 days

Dopamine antagonism

31
Q

First line Tx for Neuroleptic Malignant Syndrome

A

Diphenhydramine

Pharmacology by THer (31 decks)

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