PRINCIPLES OF ANTIMICROBIAL THERAPy Flashcards
lowest concentration of antibiotic
A. Minimum Inhibitory Concentration (MIC)
B. Minimal Bactericidal Concentration (MBC)
A
does not kill the organism
A. Minimum Inhibitory Concentration (MIC)
B. Minimal Bactericidal Concentration (MBC)
A
minimum concentration of antibiotic
A. Minimum Inhibitory Concentration (MIC)
B. Minimal Bactericidal Concentration (MBC)
B
arrest the growth & replication of bacteria at serum level achievable in the patient, limiting the spread of infection
A. BACTERIOSTATIC DRUGS
B. BACTERICIDAL DRUGS
A
CHON synthesis inhibitors
A. BACTERIOSTATIC DRUGS
B. BACTERICIDAL DRUGS
A
→ kill the bacteria at drug serum level achievable in the patient
→ more aggressive
A. BACTERIOSTATIC DRUGS
B. BACTERICIDAL DRUGS
B
cell wall synthesis inhibitors
A. BACTERIOSTATIC DRUGS
B. BACTERICIDAL DRUGS
B
T/F
the hydrophobic molecule are concentrated in the cell bilayer
and cannot enter the cell
T
T/F
the hydrophilic molecules concentrate in the blood, cytosol, or
cytoplasm and easily enter the cell
T
→ antimicrobial action must be present at the wound site at the time of its closure
→ preventive treatment
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
A
prophylaxis may be used to protect the healthy persons from acquisition of or invasion by specific organisms to which they are
exposed
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
A
delivery of treatment prior to development of symptoms
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
B
early treatment for patients with lab tests indicating them as an asymptomatic patient
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
B
aborts impending disease
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
B
significant risk of serious morbidity
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
C
for patients with unknown origin of infection
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
C
drug of choice is influenced by the site of infection and history
of infection of the patient
A. PROPHYLACTIC TREATMENT
B. PRE-EMPTIVE TREATMENT
C. EMPIRIC TREATMENT
D. DEFINITIVE TREATMENT WITH KNOWN PATHOGEN
E. POST-TREATMENT SUPPRESSIVE TREATMENT
C
T/F
In POST-TREATMENT SUPPRESSIVE TREATMENT initially, the disease is controlled by antimicrobial treatment and this treatment is continued at a lower dose if the infection is not yet completely eradicated
T
patients with bacterial meningitis or endocarditis is given through?
IV
patients with nausea and vomiting, gastrectomy, or disease that
may impair oral absorption is given through?
IV
persistent suppression of microbial growth after levels of antibiotics have failed below MIC
A. Post-Antibiotic Effect
B. Time-Dependent Killing
C. Concentration-Dependent Killing
A
acting only single or limited group of organisms
A. narrow-spectrum antibiotics
B. extended-spectrum antibiotics
C. broad-spectrum antibiotics
A
effective against Gram (+) organisms and Gram (-)
organisms
A. narrow-spectrum antibiotics
B. extended-spectrum antibiotics
C. broad-spectrum antibiotics
B
greater coverage for plenty of microbial species
A. narrow-spectrum antibiotics
B. extended-spectrum antibiotics
C. broad-spectrum antibiotics
C
maximal level of antibiotic that can be tolerated by the host does not halt the growth of the pathogen
DRUG RESISTANCE
indicated for individuals who are at high risk for temporary exposure to selected virulent pathogens & in patients who are at high risk for developing infection because of underlying disease (ex.: endocarditis)
NON-SURGICAL PROPHYLAXIS
