LESSON 3 & 5 (M) Flashcards
It has 3 division which are:
Sympathetic
Parasympatheti c
Enteric
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
“fight-flight” response
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
neurotransmitter: norepinephrine or
noradrenaline
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
B
majority of the sympathetic fibers are adrenergic
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
craniosacral outflow
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
“rest-digest” response
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
neurotransmitter: acetylcholine
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
True or false
Both are under CHOLINERGIC AGONISTS
When the Sympathetic is stimulated, there is increase in BP, HR, and respiratory rate. While the Parasympathetic when stimulated, there is decrease in BP and HR
True
also known as the brain of the gut
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
myenteric (Auerbach’s) plexus
submucosal (Meissner’s) plexus
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
act on the receptors activated by acetylcholine
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
choline acetyltransferase catalyzes the reaction of choline with acetyl coenzyme A
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
packaged into presynaptic vesicles
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
release of their contents into synaptic space
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
diffuses across synaptic space & binds to either postsynaptic receptors on target cell or to presynaptic receptors in the membrane that released the acetylcholine
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
→ choline & acetate
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
may be recaptured by the Na-coupled, high affinity uptake system
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
SYNAPSE
→ a communication between the neuron and the effector cell
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
found in the axon terminal
PRESYNAPTIC MEMBRANE
P
found in the effector or target cell
POSTSYNAPTIC MEMBRANE
parts of a synapse are the: (1) presynaptic membrane and
(2) postsynaptic membrane
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
→ area of myelinated axon which is not myelinated
→ does not have a covering of myelin or no myelin sheath
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
the other part of the axon that is not covered with myelin is
the _______
node of Ranvier
Once the action potential arrives at the nerve ending, then there is now an influx of ____ into the cell
calcium
→ Muscarinic Receptors
→ Nicotinic Receptors
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
→ Muscarinic Receptors
→ Nicotinic Receptors
milliseconds; chemical synapse; found in cell membrane
(extracellular)
NICOTINIC RECEPTORS
second messengers/neuromodulators amplify the duration
and intensity of the signal
MUSCARINIC RECEPTORS
primarily on autonomic effector cells innervated by
postganglionic parasympathetic nerve
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
M1 Receptors
M2 Receptors
M3 Receptors
M4 & M5 Receptors
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
→ “neural”
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B. ADRENERGIC AGONISTS
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M1 receptors
→ “cardiac”
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
M2 receptor
“glandular/smooth muscle”
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
M3 receptor
CNS
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
M4 & M5 receptors
True or false
Acetylcholine promotes the secretion of hydrochloric acid by the parietal cells in the stomach.
True
True or false
The action of cholinergic agonists on the heart is to decrease the heart rate and decrease the cardiac contraction meaning (-) negative chronotropic and (-) negative inotropic.
True
CHOLINOMIMETIC DRUGS
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
bind to and active muscarinic or nicotinic receptors
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
Direct-Acting Cholinomimetic
produce their primary effects by inhibiting acetylcholinesterase which hydrolyzes acetylcholine to choline & acetate
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
Indirect-Acting Cholinomimetic
Naturally- Occurring Alkaloids
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
o Pilocarpine
o Muscarine
o Arecholine
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
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(-) chronotropic and (-) inotropic effect.
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
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→ bronchoconstriction
→ increase in tracheobronchial secretion
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
→ increase in voiding pressure
→ increase in ureteral peristalsis
(promotion of urination)
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
increase in GI motility and increase in HCl production in the stomach
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
increase in GI motility and increase in HCl production in the stomach
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
stimulation of secretion of lacrimal, nasopharyngeal, salivary, & sweat glands (increase in secretion)
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
in the eyes, miosis or contraction of the pupil and accommodation for near vision
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
the substance responsible for this vasodilation is the nitric oxide
(NO)
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
BETHANECHOL
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
therapeutic uses:
o treatment of urinary retention & inadequate emptying in
post-op urinary retention
o stimulates peristalsis, increase in motility, increase in resting
lower esophageal sphincter pressure
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A.
BETHANECHOL
therapeutic uses:
o miotic agent to treat glaucoma by causing pupillary
contraction & decrease in intraocular pressure
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
CARBACHOL
treatment of xerostomia following head & neck radiation
treatment or associated with Sjogren syndrome
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
PILOCARPINE
XEROSTOMIA
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
a chronic autoimmune disorder that happens when the immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body.
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
SJOGREN SYNDROME
terminates the action of acetylcholine
acetylcholinesterase
inhibit the action of cholinesterases
anticholinesterase
True or false
by inhibiting acetylcholinesterase, they increase the endogenous acetylcholine concentration in the synaptic clefts and neuroeffector junctions
True
→ Edrophonium
→ Tacrine
→ Donepezil
→ Propidium
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
Reversible Inhibitors
→ Physostigmine
→ Neostigmine
→ Rivastigmine
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
Carbamoylating Inhibitors
→ Soman
→ Sarin
→ Malathion
→ Echothiophate
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
Organophosphate Inhibitors
atony of smooth muscle of GIT & UB
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
thus can penetrate the blood-brain barrier
A. CHOLINERGIC AGONISTS
B. ADRENERGIC AGONISTS
A
PHYSOSTIGMINE