CNS Flashcards
analeptics or convulsants
A. Cns
B. Opiods
CNS STIMULANTS
effect of blockade of transmitter catabolism inside nerve terminal
PRESYNAPTIC SITES
effect of blockade of reuptake or degradation
PRESYNAPTIC SITES
receptor antagonism is a common mechanism of action for CNS drugs
POSTSYNAPTIC SITES
Theophylline
Theobromine
Caffeine
METHYLXANTHINES
most widely used psychoactive drug in the world
CAFFEINE
→ 2nd to caffeine as most widely used CNS stimulant
→ 2nd to alcohol as most abused drug
NICOTINE
an inactive metabolite, can be used as a measure of smoking habits.
Cotinine
blocks the reuptake of monoamines
COCAINE
powerful stimulant
COCAINE
“fight/flight” syndrome
COCAINE
o major urinary metabolite
o can be found in the urine for 2-5 days after a binge
benzoylecgonine
detects cocaine use
benzoylecgonine test
has a significant teratogenic effect on the fetus
COCAINE
freely penetrates the BBB
AMPHETAMINE
used to be utilized as an appetite suppressant in obese
patients; because of its congenital anomalies, it was discontinued in such cases
AMPHETAMINE
USES
→ in an ADHD-child that is hyperkinetic & lacks the ability to be involved in any one activity for longer than a few minutes
AMPHETAMINE
derivative of amphetamine
methylphenidate
most commonly used & abused psychomotor stimulant
METHAMPHETAMINE
Shabu
METHAMPHETAMINE
ecstasy
3,4-METHYLENEDIOXYMETHAMPHETAMINE
preferential affinity for serotonin transporter → increasing
serotonin concentration
3,4-METHYLENEDIOXYMETHAMPHETAMINE
excess water intake & water retentions → “water intoxication” → coma
3,4-METHYLENEDIOXYMETHAMPHETAMINE
psychedelic agents or psychomimetic drugs
HALLUCINOGENS
