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PHARMA > Opiods > Flashcards

Opiods Flashcards

1
Q

morphine, codeine, thebaine

A

Opiates

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2
Q

compounds structurally related to products found in opium

A

Opiates

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3
Q

substances that are endogenous/synthetic that produce morphine-like effects that are blocked by antagonists such as naloxone

A

Opioids

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4
Q

derived from beta lipoprotein

A

endorphins

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5
Q

o newly discovered
o localized in areas in the CNS associated with pain

A

endormorphines

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6
Q

first discovered opioid peptides

A

enkephalins

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7
Q

site at which all the currently available pure agonists act to produce analgesia

A. MU RECEPTORS
B. KAPPA RECEPTORS
C. DELTA RECEPTORS

A

MU RECEPTORS

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8
Q

responsible for most of the analgesic effects of opioids & for some major unwanted effects

A. MU RECEPTORS
B. KAPPA RECEPTORS
C. DELTA RECEPTORS

A

MU RECEPTORS

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9
Q

o dysphoria
o hallucinations

A. MU RECEPTORS
B. KAPPA RECEPTORS
C. DELTA RECEPTORS

A

B

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10
Q

can be preconvulsant

A. MU RECEPTORS
B. KAPPA RECEPTORS
C. DELTA RECEPTORS

A

C

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11
Q

opioid antagonist

A

naloxone

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12
Q

related to pain or is painful stimuli

A

nociceptive stimuli

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13
Q

has direct effect on the heart because of its antimuscarinic action → tachycardia

A

MEPERIDINE

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14
Q

equal in potency to morphine but less euphoria & longer
duration of action

A

METHADONE

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15
Q

→ 100-fold analgesic potency of morphine

A

FENTANYL

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16
Q

→ highly lipophilic

→ metabolized by cytochrome P-450

A

FENTANYL

17
Q

True or false

FENTANYL is use for anesthetic and management of severe pain

A

True

18
Q

→ more lipid soluble than morphine
→ 3x more potent than morphine
→ more euphoria

A

HEROIN (DIACETYLMORPHINE)

19
Q

sometimes formulated with Aspirin or Acetaminophen

A

OXYCODONE

20
Q

→ used in management of severe pain
→ metabolized and excreted through the kidneys

A

OXYCODONE

21
Q

often used in combination with Aspirin or Acetaminophen

A

CODEINE

22
Q

→ less potent analgesic and less euphoria than morphine
→ lower potential for abuse than morphine
→ greater oral efficacy because of lower first pass metabolism in the liver

A

CODEINE

23
Q

often used in combination with Aspirin & Acetaminophen for analgesia

A

PROPOXYPHENE

24
Q

k receptor agonist

A

PENTAZOCINE

25
Q

a partial agonist acting at mu receptor

A

BUPRENORPHINE

26
Q

25-50x more potent than morphine

A

BUPRENORPHINE

27
Q

major use:
o opiate detoxification

A

BUPRENORPHINE

28
Q

→ treatment of chronic pain
→ exhibit a ceiling effect

A

NALBUPHINE & BUTORPHANOL

29
Q

effective in labor pains & causes less neonatal depression

A

TRAMADOL

30
Q

competitive antagonist with a 10-fold affinity for mu receptors than kappa receptors

A

NALOXONE

31
Q

“renarcotization”

A

NALOXONE

32
Q

→ in combination with buprenorphine → used for rapid opioid detoxification

→ beneficial in the treatment of chronic alcoholism

A

NALTREXONE

PHARMA (15 decks)

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