Primer 0 Flashcards
Name 7 teratogens.
[A Valiant Punks Lidia Till We Exile]
- ACE inhibitors
- Valproate
- Phenytoin
- Lithium
- Tetracycline
- Warfarin
- Excess vit A.
Which areas of the hypothalamus regulate the autonomic nervous system?
Anterior hypothalamus: Controls the parasympathetic nervous system.
Posterior hypothalamus: Controls the sympathetic nervous system.
What is the classic clinical presentation of a thyroglossal duct cyst?
Asymptomatic midline neck mass.
What conditions are associated with an elevated ESR (erythrocyte sedimentation rate)?
- Infection, inflammation, neoplasm.
- Osteomyelitis
- Polymyalgia rheumatica
- Temporal arteritis
- Rheumatoid disease.
What is the clinical use for tiotropium?
Inhaled anticholinergic drug used in COPD.
What abnormality is associated with the buzzword “Boot-shaped heart”?
Right ventricular hypertrophy.
What abnormality is associated with the buzzword “continuos machine-like murmur”?
PDA
What abnormality is associated with the buzzword “tendon xanthomas”?
Familial hypercholesterolemia.
What abnormality is associated with the buzzword “Cafe-au-lait spots”?
Neurofibromatosis type 1 as well as McCuna-Albright.
What abnormality is associated with the buzzword “tuft of hair on back”?
Spina bifida occulta.
What structures are at risk for injury with an anterior shoulder dislocation?
Axillary nerve Posterior circumflex artery Supraspinatus tendon Anterior glenohumeral ligament Glenoid labrum Posterolateral humeral head
What are the layers of the epidermis?
[CLGSB] [Californians Like Girls in String Bikinis].
Corneum Lucidum Granulosum Spinosum Basalis
What clinical presentations might lead you to suspect a patient may have lymphoma?
Painless lymphadenopathy
Fever
Weight loss
Night sweats
What form of leukemia matches “Most common leukemia in children”?
ALL (acute lymphoblastic leukemia).
What form of leukemia matches “Most common leukemia in adults in US”?
CLL (chronic lymphoblastic leukemia).
What form of leukemia matches “characteristic Auer rods”?
AML (acute myeloid leukemia).
What form of leukemia matches “greated than 20% blasts in marrow”?
Acute leukemia (AML or ALL)
What form of leukemia matches “Leukemia with more mature cells and less than 5% blasts”?
Chronic leukemia (CML or CLL)
What form of leukemia matches “PAS (+) acute leukemia”?
ALL (acute lymphoblastic leukemia).
What brain structure is responsible for extraocular movements during REM sleep?
Paramedian pontine reticular formation (PPRF).
What form of leukemia matches “always positive for the Philadelphia chromosome (t 9;22)”?
CML (chronic myelogenous leukemia)
What form of leukemia matches “acute leukemia for peroxidase”?
AML (acute myelogenous leukemia)
What form of leukemia matches “solide sheets of lymphoblasts in marrow”?
ALL (acute lymphoblastic leukemia)
What form of leukemia matches “always associated with BCR-ABL genes”?
CML (chronic myelogenous leukemia)
What histological change takes place in the trachea of a smoker?
[Smokers play Counter Strike]
Columnar to squamous metaplasia.
A 55-year old man who is a smoker and heavy drinker presents with a new cough and flu-like symptoms. Gram stain shows no organisms; silver stain of sputum shows gram-negative rods. What is the diagnosis?
Legionella pneumophila (Legionnaire’s disease)
What is the classic presentation of a patient with temporal arteritis? What lab findings help diagnose temporal arteritis?
Unilateral headache and jaw claudication. Blindness or impaired vision at later stages of the disease.
Labd: Elevated SED rate. Temporal artery biopsy for definitive diagnosis.
A 30-year-old woman presents with a low grade fever, a rash across her nose that gets worse when she is out in the sun, and widespread edema. What blood test would you order to confirm your clinical suspicion?
ANA. Think of lupus.
In the dark, both pupils are dilated. In the light, the control pupil is miotic white the pupil given drug X remains mydriatic. What drug is X?
X can be a sympathetic agonist like epinephrine or it can be an anticholinergic like atropine.
What are some of the clinical uses for somatostatin?
- Pituitary excess: Acromegaly, TSH-secreting tumor, ACTH-secreting tumor.
- GI endocrine excess: Carcinoid syndrome, Zollinger-Ellison syndrome, VIPoma, glucagonoma, insulinoma.
- Diarrhea (off-label)
- Reduces splanchnic blood circulation: Cirrhosis with bleeding esophageal varices, and bleeding peptic ulcers.
What is the name given to a thyroid-secreting teratoma?
Struma ovarii
Where does erythropoiesis take place in the fetus? Which bones in adults synthesize RBCs?
Fetus: [Young Liver Synthesizes Blood]
- Yolk sac
- Liver
- Spleen
- Bone marrow
Adult: Vertebrea, sternum, pelvis, ribs, cranial bones, tibia and femur.
What adult structures are derived from the 3rd aortic arch?
Common carotid artery
Proximal part of internal carotid
What adult structures are derived from the 4th aortic arch?
Left: Aortic arch
Right: Proximal part of right subclavian artery.
What adult structures are derived from the 5th aortic arch?
No adult structure.
What adult structures are derived from the 6th aortic arch?
Proximal part of pulmonary arteries
Ductus arteriosus
What cell wall inhibitor is used in next step in treatment of otitis media if resistant to amoxicillin?
Amoxicillin with clavulanic acid.
What cell wall inhibitor is used in prophylaxis against bacterial endocarditis?
Penicillin V, aminopenicillin, 1st gen cephalosporin.
What cell wall inhibitor increases the nephrotoxicity of aminoglycosides?
Cephalosporins
What cell wall inhibitor is sufficient for the treatment of syphilis?
Penicillin G
What cell wall inhibitor is used in single dose treatment for gonorrhea?
Ceftriaxone
What germ layer gives rise to the retina?
Neuroectoderm.
What germ layer gives rise to the salivary glands?
Surface ectoderm
What germ layer gives rise to the pancreas?
Endoderm
What germ layer gives rise to the muscles of the abdominal wall?
Mesoderm
What germ layer gives rise to thymus?
Endoderm
What germ layer gives rise to spleen?
Mesoderm
What germ layer gives rise to the aorticopulmonary septum?
Neural crest
What germ layer gives rise to the anterior pituitary gland?
Surface ectoderm.
What germ layer gives rise to posterior pituitary gland?
Neuroectoderm
What germ layer gives rise to the bones of the skull?
Neural crest
What germ layer gives rise to the cranial nerves?
Neural crest
What are the clinical for 1st generation cephalosporins?
[PEK] Proteus mirabilis E. coli Klebsiella pneumoniae G(+) cocci
What are the clinical uses for 2nd generation cephalosporins?
[HEN PEKS]
H. influenzae
Enterobacter
Neisseria sp.
Proteus mirabilis E. coli Klebsiella Serratia marcescens G(+) cocci
What are the clinical uses for 3rd generation cephalosporins?
Serious G(-) infections Pseudomonas Neisseria gonorrhea
What are the clinical uses for 4th generation cephalosporins?
G(+) infections
G(-) infections
Pseudomonas
What are the classical symptoms of carcinoid syndrome?
[Carcinoid is Big Fucking Deal, Right?]
Bronchospasms and wheezing
Flushing
Diarrhea
Right sided heart murmurs or lesions
What is the target HgbAIC for every diabetic patient?
Less than 7.0
What are the five hereditary thrombosis syndromes?
- Factor V Leiden
- Prothrombin 20210 mutation
- Protein C deficiency
- Protein S deficiency
- Antithrombin deficiency
Which Mycobacterium spp. causes leprosy?
Mycobacterium leprae.
Which Mycobacterium spp. causes pulmonary TB-like symptoms in COPD patients?
Mycobacterium kansasii
Which Mycobacterium spp. causes a cervical lymphadenitis in children?
Mycobacterium scrofulaceum.
Which Mycobacterium spp. causes a disseminated disease in AIDS patients?
Mycobacterium avian complex (MAC)
Mycobacterium avian intracelulari (MAI)
Which Mycobacterium spp. causes hand infection in aquarium handlers?
Mycobacterium marinum.
What are the 3 different mechanisms cell employ to break down proteins?
- Ubiquitin protein ligase.
- Lysosomes
- Calicum-dependent enzymes.
Which medication used in the treatment of HIV is know for causing bone marrow suppression?
Zidovudine (AZT) is the most common.
What is the treatment for lead poisoning?
Adults: Succimer or EDTA
Children: Succimer, EDTA, Dimercaprol
What enzyme catalyzes peptide bond formation during synthesis?
Peptidyl transferase
What conditions are associated with target cells?
[HALT] HbC disease Asplenia Liver disease Thalassemia
What name is given to anemia resulting from mechanical destruction of erythrocytes due to aortic stenosis or prosthetic heart valves?
Macroangiopathic anemia.