Primary Sclerosing Cholangitis Flashcards
1
Q
Describe what happens in PSC
A
inflammation and fibrosis of intra and extra-hepatic bile ducts.
2
Q
Conditions associated with PSC
A
UC
Crohn’s (much less common than UC)
HIV
3
Q
Clinical features of PSC
A
cholestasis
jaundice, pruritus
raised bilirubin + ALP
right upper quadrant pain
fatigue
4
Q
What imaging can be used to diagnose PSC?
A
MRCP/ERCP
- show multiple biliary strictures giving a ‘beaded’ appearance
5
Q
What would a liver biopsy show in PSC (although infrequently used)
A
fibrous, obliterative cholangitis often described as ‘onion skin’
6
Q
What antibody may be positive in PSC
A
p-ANCA
7
Q
Patients with PSC are at increased risk of what types of cancer?
A
cholangiocarcinoma
colorectal cancer
8
Q
A
