Gilbert's Syndrome

Question 1

How is gilbert’s syndrome inherited

Answer 1

autosomal recessive

Question 2

What is gilbert’s syndrome

Answer 2

defective bilirubin conjugation
due to a deficiency of UDP glucuronosyltransferase.

Question 3

Features of gilbert’s syndrome

Answer 3

• unconjugated hyperbilirubinaemia
• jaundice during an intercurrent illness, exercise or fasting

Question 4

Investigation findings in Gilbert’s syndrome

Answer 4

• rise in bilirubin following prolonged fasting or IV nicotinic acid

Question 5

Gilbert’s syndrome management

Answer 5

no treatment required