Primary Hyperparathyroidism

Question 1

What is primary hyperparathyroidism?

Answer 1

Bone resorption due to inappropriate secretion of PTH

Question 2

What are the histiologic bone changes that occur in primary hyperthyroidism?

Answer 2

Osteitis fibrosa

Question 3

What is the primary cause of primary hyperparathyroidism?

Answer 3

Parathyroid adenomas

Question 4

What effect does PTH have on the kidney?

Answer 4

Increase calcium reabsorption and increase 1Alpha-Hydroxylase activity (increasing active Vit D)

Question 5

What is a “brown tumor” associated with?

Answer 5

Endstage of primary hyperparathyroidism in which areas of fibrosis contain reactive woven bone and heosiderin-laden macrophages

Question 6

What is the classic finding of osteitis fibrosa cystica?

Answer 6

Presence of multiple, localized, lytic lesions, which represent hemorrhagic cysts or masses of fibrous tissue

Question 7

What are the classic clinical findings of primary hyperparathyroidism?

Answer 7

Stones, Moans, Bones, and Groans