Osteoporosis

Question 1

What is osteoporosis?

Answer 1

Metabolic bone disease in normally mineralized bone is decreased in mass to the point that it no longer provides adequate mechanical support

Question 2

What is the general underlying mechanism of osteoporosis?

Answer 2

Enhanced bone resorption relative to formation

Question 3

What is the most common variety of osteoporosis? Cause?

Answer 3

Primary; Unknown etiology

Question 4

What is secondary osteoporosis?

Answer 4

Osteoporosis associated with a defined cause (ie endocrine)

Question 5

What is the ratio of osteoclast/osteoblast activity in primary and secondary osteoporosis?

Answer 5

1. Primary - increased osteoclast activity
2. Secondary - decreased osteoblast activity

Question 6

What are the two major determinants of primary osteoporosis?

Answer 6

Estrogen deficiency in women and aging process in both sexes

Question 7

What is the ratio of osteoid to mineralized bone in osteoporosis?

Answer 7

Normal

Question 8

What is the name of the bone lesion in which vertebral body compression fractures resulting in shorter stature and kyphosis?

Answer 8

Dowager’s hump

Question 9

Most common cause of secondary osteoporosis?

Answer 9

Iatrogenic corticosteroid administration

Question 10

What are causes of secondary osteoporosis?

Answer 10

1. Endocrine
2. Hyperparathyroidism
3. Hyperthyroidism
4. Hypogonadism
5. Hematologic malignancies
6. Malabsorption
7. Alcoholism