Bone Formation and Growth

Question 1

What is the name of the process which cartilage is resorbed and replaced by bone?

Answer 1

Endochondral ossification

Question 2

Briefly describe the process of primary ossification

Answer 2

1. Primary cartilage anlage laid down
2. Primary center of ossification forms
3. Cylinderization
4. Primary spongiosum is laid down

Question 3

Describe the process of secondary ossification

Answer 3

1. Secondary center of ossification forms in the epiphysis
2. The growth plate forms

Question 4

What are the cellular layers of the growth plate from epiphysis to diaphysis?

Answer 4

• Resting zone
• Proliferative zone
• Hypertrophic zone - substantial increase in chondrocyte size
• Zone of calcification
• Zone of ossification

Question 5

What is the name of the process which the metaphysis is formed?

Answer 5

Funnelization

Question 6

What determines adult height?

Answer 6

The growth plate