Langerhans Cell Histiocytosis Flashcards
1
Q
What is an awesome name for Langerhans Cell Histiocytosis?
A
Histiocytosis X
2
Q
What are the three entities of LCH?
A
- Eosinophilic Granuloma
- Hand-Schueller-Christian Disease
- Letterer-Siwe Disease
3
Q
What are the racket-shaped tubular structures seen on EM in LCH diseases?
A
Birbeck granules
4
Q
What type of bone lesions are seen in LCH?
A
punched-out lytic defects
5
Q
What cells are characteristic in LCH?
A
Multinucleated osteoclastic giant cells
6
Q
What disease accounts for most cases of LCH?
A
Eosinophilic granuloma
7
Q
Classic triad of Hand-Schueller-Christian Disease?
A
- Radiolucent Lesions of the Skull
- Diabetes Insipidus
- Exophthalmos
8
Q
What is the Px for Leterer-Siwe Disease?
A
Aggressive and Potentially Fatal disease
