Presynaptic

Question 1

neostigmine

Answer 1

anit-cholinesterase

Question 2

normal impulse releases about how many vesicles

Answer 2

100

Question 3

hemicholinium: category, resembles what?

Answer 3

presynaptic (blocks choline uptake); Myasthenia Gravis

Question 4

Myasthenia Gravis

Answer 4

Loss of Ach receptors, quick to fatigue

Question 5

Tetrodotoxin

Answer 5

blocks Na channel involved in upstroke of AP

Question 6

Effect of Mg++ and other polyvalent cations

Answer 6

block Ca entry

Question 7

Aminoglycoside antibiotics: some examlples and their effect

Answer 7

neomycin and other -mycins. Block Ca entry

Question 8

LEMS

Answer 8

Reduced number of Ca channels in nerve ending. Initial strength is low but improves with repetitive action.

Question 9

Black widow spider venom: actual name, effect

Answer 9

alpha-latrotoxin. Causes barrage of ach and MEPPs then they get depleted

Question 10

Botulinum toxin A: target, effect, why?

Answer 10

SNAP-25. Reduces the affinity for Ca so exocytosis is impaired. Cleaves near the Ca sensor

Question 11

Blepharospasm

Answer 11

orbic oculi contractions, tx w/ botox

Question 12

how to differentiate prejuctional from post junctional

Answer 12

if EPP, MEPP, and response to exogenous ACh all decrease in parallel, it is post junctional. If EPP/MEPP is decreased, its prejuctional

Question 13

what is the Ca sensor of the SNARES called

Answer 13

synaptotagmin