CT dz and autoimmune conditions

Question 1

most common form of chronic LE. More common in___

Answer 1

Discoid. AA females

Question 2

Discoid LE: lesions

Answer 2

scaly, pink-brown. Heal with dyspigmented scars

Question 3

Subacute cutaneous LE: lesions, associated abs, causes

Answer 3

scaly, annular pink papules and plaques. NO scars. Anti-Ro abs. Drug induced, sun exposure

Question 4

Acute cutaneous LE: presentation, triggers, associated abs, next step

Answer 4

classic malar rash (cheeks and nose, spares folds), transient presentation, sun exposure, anti-dsDNA. Evaluate for SYSTEMIC dz

Question 5

Neonatal LE: mothers have ___ ab, presentation, next step

Answer 5

Anti-Ro, annular pink scaly plaques. Evaluate for INTERNAL dz! (heart block!, do EKG)

Question 6

dermatomyositis: what can it mean in adults? signs and symptoms?

Answer 6

occult malignancy. Proximal muscle weakness, heliotrope rash, gottron’s papules (scaling, on extensor joints), mechanic’s hands, poikiloderma

Question 7

dermatomyositis: internal manifestations

Answer 7

myopathy, pulm dz, cardiac dz, calcinosis, malignancy (not JDM)

Question 8

Relapsing polychondritis: pathogenesis? problem? Classic presentation

Answer 8

autoimmune, cartilage structures. Ear all red except LOBE

Question 9

Sjogrens: three most common features

Answer 9

xerostomia, xerophthalmia, arthritis.

Question 10

Systemic Sclerosis: two types.

Answer 10

diffuse and limited cutaneous.

Question 11

SSC: Where does limited affect? which displays CREST? Which displays anti-centromere?

Answer 11

fingers, hands, face; limited; limited.

Question 12

CREST

Answer 12

calcinosis cutis, raynauds, esophageal dysmotility, sclerodactyly, telangectasia

Question 13

Morphea: how does it differ from SSc?

Answer 13

no rayauds, no internal organs, just skin

Question 14

HSP: what precedes it? Characteristics? can lead to? what deposits?

Answer 14

URI, palpable purpura, Leukocytoclastic purpura, IgA

Question 15

Granulomatosis with Polyangitis: what kind of ANCA? Triad of symptoms?

Answer 15

c-ANCA (PR3). Upper and lower RT inflammation, systemic necrotizing vasculitis, glomerulonephritis

Question 16

Churg-Strauss Syndrome: ANCA? Stages:

Answer 16

pANCA (MPO). 1: allergic rhinits, nasal polyps, asthma. 2: peripheral eosinophilia, respiratory tract. 3: Systemic vasculitis

Question 17

Sarcoidosis: biopsy shows? Specific lesions?

Answer 17

non-caseating granulomas. lupus pernio (nasal tip papules)

Question 18

Lupus pernio: seen in? associated with?

Answer 18

sarcoid. Pulmonary dz (do pfts)

Question 19

Erythema nodosum: what? where? ulcers? seen in?

Answer 19

erythematous subq nodules. pretibial, no ulcers, sarcoid and others.