immunity and psoriasis

Question 1

barrier protein in the stratum corneum (disrupted in atopic dermatitis)

Answer 1

filaggrin

Question 2

anti microbial proteins in strat corneum

Answer 2

defensins

Question 3

after passing stratum corneum, what must microbe do? What happens as consequence

Answer 3

separate tight jxns. Triggers cytokine release and TLR activation

Question 4

TLR activation produces what cytokines? Dendritic cells produce___ (switch). This then stimulates production of ___ (upregulator)

Answer 4

TNF-alpha. IL23. IL 17

Question 5

name four variants of psoriasis

Answer 5

plaque, pustular, erythrodermic, guttate (following strep)

Question 6

three characteristics of psoriasis clinical presentation

Answer 6

scale (abnormal keratin expression), thickness (rapid keratinocyte prolif.), redness (cutaneous vascular proliferation)

Question 7

what is the link b/w activated keratinocytes and immunocytes in psoriasis. What activates it?

Answer 7

STAT3. activated by IL-23

Question 8

name some popular psoriasis treatments?

Answer 8

topical corticosteroids, phototherapy, biologics like etanercept, infliximab, ustekinumab