dry, itchy skin

Question 1

mutations in filaggrin cause what dz?

Answer 1

Ichtyosis vulgaris. ~13% of eczema

Question 2

What are the mainstay of tx in atopic derm? What are the risks? Maintenance therapy?

Answer 2

Topical steroids. Atrophy, striae, dyspigmentation, hypertrichosis. Tacrolimus twice weekly

Question 3

three fxns of filaggrin

Answer 3

binds intermediate filaments for lipid cell envelope, degrades in natural moisturizing factor, breaks down into acids to maintain pH

Question 4

what happens to keratinocytes differentiated in the presence of IL-4 and IL-13?

Answer 4

reduced filaggrin expression. functional deficiency

Question 5

four major tx classes for atopic derm

Answer 5

anti-infalmmatory, moisturization, antibiotics, antipruritics

Question 6

Allergic contact dermatitis: what type of inflammatory rxn? How long does it take to appear?

Answer 6

type 4 (delayed) t cell mediated. Takes hours to days to appear and lasts for days to weeks

Question 7

definitive test for hypersensitivity.

Answer 7

patch test

Question 8

common pattern for urticaria

Answer 8

wheal and flare

Question 9

Characteristics of urticaria: time span? dermatographism?

Answer 9

within 24 hours. hives form where you scratch