Acne

Question 1

four pillars of acne pathogenesis

Answer 1

follicular epidermal hyperproliferation, excess sebum, inflammation, P. acnes

Question 2

What role do androgens (testosterone) play in acne?

Answer 2

they stimulate the sebaceous gland to produce sebum

Question 3

what does P. acnes do with sebum. How else do they contribute to inflamm

Answer 3

converts the Triglycerides into FFAs which contribute to inflamm. Activate TLRs which bring in cytokines

Question 4

non-inflammatory and inflammatory lesions in acne

Answer 4

Non- comedones. Inflammatory- papules and pustules, nodules and cysts

Question 5

Polycystic ovary syndrome

Answer 5

too many androgens. Can look like acne vulgaris but you get facial hair and alopecia

Question 6

First, second, severe treatments for acne

Answer 6

topical retinoid, oral antibiotics, oral isotretinoin

Question 7

hormonal acne treatments

Answer 7

combination birth control pills, spironolactone (androgen blocker)

Question 8

Acne Rosacea: pathogenesis. symptoms. tx

Answer 8

unknown but cathelicidins are elevated. Redness, telangiectases. papules and pustules but NO COMEDONES

Question 9

Perioral dermatitis: aggravating factors. Tx

Answer 9

topical glucocorticoids! Give topical agensts or oral antibiotics

Question 10

hidradenitis suppurativa: who? where? what?

Answer 10

females, axillae/breast/inguinal/buttocks. tender red draining nodules and abcesses