Prescribing in pregnancy Flashcards
what drugs cross the placenta?
most
except large molecular weight e.g. heparin
pharmacokinetics in pregnancy
absorption may be affected by morning sickness
Increased plasma volume and fat stores, so Volume of distribution increases
Decreased protein binding - increased free drug
Increased liver metabolism of some drugs - Phenytoin
Elimination of renally excreted drugs increases - increased GFR
when is the period of greatest teratogenic risk of drugs
4th-11th week
is insulin safe in pregnancy?
yes
are sulfonylureas safe in pregnancy
no. convert to insulin
hypertension drugs used in pregnancy
labetalol
methyldopa
are ACEi safe in pregnancy
no
first line treatment for nausea and vomiting
cyclizine
UTI treatment
Nitrofurantoin first-line, amoxicillin or cefalexin second-line
which women are given LWMH for VTE risk
2 or more risk factors eg obesity, age>35yrs, smoking, para >3, previous DVT, Caesarean delivery
is warfarin safe in pregnancy
no
VTE treatment in pregnancy
LMWH
should tetracycline been given in pregnancy
no - can cause the black teeth staining
which antiepileptic drug is particularly associated with cleft lip and palate?
phenytoin
which antiepileptic drug is particularly associated with spina bifida and anencephaly
valproate
