Prescribing in... Flashcards
What antibiotics can’t be used in pregnant patients?
tetracyclines
aminoglycosides
sulphonamides and trimethoprim
quinolones
What other drugs cant be used in pregnant patients?
ACE inhibitors, angiotensin II receptor antagonists statins warfarin sulfonylureas retinoids (including topical) cytotoxic agents
What needs to be considered in epileptic pregnant patients?
The majority of anti epileptics are known to be potentially harmful, but decision to stop must be balanced against risk of uncontrolled epilepsy
What are the non-drug contraindications to breastfeeding?
Galactosaemia
Viral infections e.g. HIV
What antibiotics can be given to mothers who are breastfeeding?
penicillins
cephalosporins
trimethoprim
What endocrine drugs can be given to mothers who are breastfeeding?
glucocorticoids
levothyroxine
what epilepsy drugs can be given to mothers who are breastfeeding?
sodium valproate
carbamazepine
what asthma drugs can be given to mothers who are breastfeeding
salbutamol
theophyllines
what psychiatric drugs can be given to mothers who are breastfeeding
tcas
antipsychotics
what hypertension drugs can be given to mothers who are breastfeeding
beta blockers
hydralazine
what anticoagulants can be given to mothers who are breastfeeding
warfarin
heparin
is digoxin safe in breastfeeding mothers
yes
what antibiotics should be avoided in breastfeeding mothers
ciprofloxacin
tetracycline
chloramphenicol
sulphonamides
what psychiatric drugs should be avoided in breastfeeding mothers
lithium
benzodiazepines
what other drugs should be avoided in breastfeeding mothers
carbimazole methotrexate sulphonylureas cytotoxic drugs amiodarone
what drugs may exacerbate heart failure
pioglitazone verapamil nsaids glucocorticoids flecainide
what drugs should be used with caution in asthma/copd
nsaids
beta blockers
adenosine
what drugs should be avoided in renal failure
tetracycline and nitrofurantoin
nsaids
lithium
metformin
what drugs are likely to accumulate in chronic kidney disease
most antibiotics digoxin atenolol methotrexate sulphonylureas furosemide opioids
what drugd are relatively safe in kidney failure
erythromucin and rifampicin
diazepam
warfarin
what drugs might worsen seizure control in epilepsy
alcohol, cocaine, amphetamines ciprofloxacin, levofloxacin aminophylline, theophylline bupropion methylphenidate (used in ADHD) mefenamic acid
what drugs might provoke seizures when they are withdrawn?
benzos
baclofen
hydroxyzine
what drugs should be used with caution in ischaemic heart disease
nsaids
oestrogens
varenicline
what drugs are inducers of the P450 system (decrease INR)
antiepileptics: phenytoin, carbamazepine
barbiturates: phenobarbitone
rifampicin
St John’s Wort
chronic alcohol intake
griseofulvin
smoking
what drugs are inhibitors of the P450 system
antibiotics: ciprofloxacin, clarithromycine/erythromycin isoniazid cimetidine,omeprazole amiodarone allopurinol imidazoles: ketoconazole, fluconazole SSRIs: fluoxetine, sertraline ritonavir sodium valproate acute alcohol intake quinupristin
