Glycopeptides Flashcards
Give 2 examples of glycopeptide antibiotics
- Vancoymycin
- Teicoplanin
What is the mechanism of action of glycopeptides?
Prevent elongation of peptide chain by inhibiting incorporation of NAMA and NAG subunits into chain
Are glycopeptide antibiotics broad or narrow spectrum?
Narrow
What are glycopeptide antibiotics effective against?
Aerobic and anaerobic gram +ve bacteria
What are the routes of delivery of glycopeptide antibiotics?
PO
IV
How should glycopeptide antibiotics be administered if given IV?
Slow administration
Why should IV glycopeptides be administered slowly?
To avoid anaphylactoid reactions or red man syndrome
Should vancomycin and teicoplanin be given orally in system infections?
No, as they are not well absorbed
What are the indications for glycopeptides antibiotics?
- Infections by gram -ve pathogens
- C. Diff colitis
- Endocarditis
- Surgical prophylaxis
When should glycopeptide antibiotics be given for surgical prophylaxis?
When high risk for MRSA
Who should glycopeptide antibiotics be avoided in?
Patients with hearing loss
Can glycopeptide antibiotics be given in renal impairment?
Yes, but reduce dose
What drugs might vancomycin interact with?
- Loop diuretics
- Ciclosporin
- Tacrolimus
- Aminoglycosides
What might happen if vancoymycin is given with the drugs I just said?
Increased risk of nephrotoxicity
What should be done if there is prolonged administration of teicoplanin with other nephrotoxic or neurotoxic drugs?
Monitor renal and auditory function
