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Drugs - CPT Sem 4 > Antiplatelet Drugs > Flashcards

Antiplatelet Drugs Flashcards

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1
Q

Give 2 examples of anti-platelet drugs

A
  • Clopidogrel

- Ticagrelor

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2
Q

What is the mechanism of action of anti platelet drugs?

A

Inhibits ADP pathway by binding to PSY12 receptors on platelet cell membranes

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3
Q

What is the importance of the ADP pathway?

A

It is needed for platelet activation and subsequent platelet aggregation

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4
Q

What is the route of delivery of anti-platelet drugs?

A

PO

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5
Q

What are the indications for antiplatelet drugs?

A
  • Primary and secondary prevention of cardioembolic events following ACS
  • Prior to coronary stenting procedures
  • To be taken for 1 year following coronary procedures
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6
Q

How is clopidogrel prescribed for primary prevention of cardioembolic events?

A

300mg prescribed with aspirin

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7
Q

What anti platelet drug is usually prescribed for secondary prevention of cardioembolic events?

A

Ticagrelor (with aspirin)

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8
Q

What are the contraindications to anti platelet drugs?

A
  • Active bleeding

- History of intracranial haemorrhage

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9
Q

When should anti platelet drugs be used with caution?

A

Hepatic and renal impairment (avoid if severe)

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10
Q

Can anti platelet drugs be used during pregnancy and breastfeeding?

A

Avoid

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11
Q

What might anti platelet drugs interact with?

A
  • Other anti platelet drugs, anticoagulants, NSAIDs, fibrinolytics, SSRIs
  • Ulcer healing drugs
  • Grapefruit juice
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12
Q

What might happen if anti-platelet drugs are given with ulcer healing drugs?

A

Reduced anti-platelet effects

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13
Q

What might happen if anti-platelet drugs are given with grapefruit juice?

A

Decreased efficacy of clopidogrel

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14
Q

What monitoring is required with anti-platelet drugs?

A
  • Monitor patients for side-effects during review appointments
  • Monitor patients renal function 1 month after starting ticagrelor
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15
Q

What are the common side effects of anti-platelet drugs?

A
  • Abdo pain
  • Bleeding
  • Diarrhoea
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16
Q

What are the less common side effects of anti-platelet drugs?

A
  • Nausea
  • Vomiting
  • Gastritis, peptic and duodenal ulceration
  • Constipation and flatulence
17
Q

What patient counselling is required with anti platelet drugs?

A
  • Side effects
  • Inform health professionals about drugs
  • Stop before surgery
  • Pregnancy and breastfeeding
18
Q

What should patients be counselled about regarding side effects with anti-platelet drugs?

A

They can bleed longer if they have an injury, and they should seek medical help if they experience severe prolonged bleeding after injury

19
Q

What should the patient be counselled about regarding informing health professionals about anti-platelet drugs?

A

They should inform the responsible clinician about taking the anti-platelet drug

20
Q

When is clopidogrel discontinued before surgery?

A

Usually 7 days before

Drugs - CPT Sem 4 (81 decks)

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