Other Antidepressants Flashcards

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1
Q

Give 2 examples of other anti-depressants

A
  • Venlafaxine

- Mirtazapine

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2
Q

What is the mechanism of action of venlafaxine?

A

Inhibits serotonin and noradrenaline re-uptake

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3
Q

What is the mechanism of action of mirtazapine?

A

Inhibits resynaptic a2-adrenoceptors

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4
Q

What is the route of delivery of venlafaxine and mirtazapine?

A

PO

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5
Q

What are the indications for venlafaxine?

A
  • Treatment of major depressive disorders following unsuccessful treatment with SSRIs
  • Generalised anxiety disorder
  • Panic disorder, with or without agoraphobia
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6
Q

What are the indications for mirtazapine?

A
  • Treatment of major depressive disorders following unsuccessful treatment with SSRIs
  • Panic disorder, with or without agoraphobia
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7
Q

What is mirtazapine particularly useful for?

A

Improving sleep in depressed patients with insomnia, and can increase appetite

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8
Q

What are the contraindications to venlafaxine?

A
  • Cardiac arrhythmias

- Uncontrolled hypertension

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9
Q

When should venlafaxine be avoided?

A

Pregnancy

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10
Q

Why should venlafaxine be avoided in pregnancy?

A

Risk of neonatal effects

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11
Q

Can venlafaxine be used in hepatic impairment?

A

Yes, with dose reduction

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12
Q

Can mirtazapine be used in hepatic impairment?

A

With caution

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