premature ovarian syndrome

Question 1

what is premature ovarian insufficiency

Answer 1

onset of menopausal symptoms and elevated gonadotrophin levels before the age of 40

Question 2

causes of premature ovarian insufficiency

Answer 2

idiopathic
bilateral oophorectomy
radiotherapy/chemotherapy
infection: mumps
autoimmune
resistant ovary syndrome: due to FSH receptor abnormalities

Question 3

presentation of premature ovarian insufficiency

Answer 3

similar to menopause
hot flushes/night sweats
infertility
secondary amenorrhoea
raised FSH/LH levels
low oestradiol

Question 4

management of premature ovarian insufficiency

Answer 4

HRT or COCP until the average age of menopause

Question 5

diagnosis of premature ovarian insufficiency

Answer 5

made on the basis of repeat raised FSH results after a period of 4-6 weeks