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BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam > Prelims exams (2023) > Flashcards

Prelims exams (2023) Flashcards

1
Q

Essential amino acids

A

A. From the diet because it cannot be synthesized by the body.

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2
Q

With which of the four complexes in the electron transport chain is FADH2 needed as a reactant

A

A. Complex II

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3
Q

PH: 7.29
PaCO2: 33
HCO3:19

A

Uncompensated metabolic acidosis

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4
Q

A 26 yrs old gave birth to a healthy term infant, overnight hypoglycemia and ketonemia developed on the 2nd and 3rd trimester. Liver biopsy revealed decreased hepatic glycogen and mutation analysis showed mutation in glycogen synthase. What specific glycogen storage disease is presented in this case?

A

Glycogen storage disease type 0

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5
Q

Salt Bridges:

A. 2-4 angstrom
B. Connection something
C. Comparable in strength to hydrogen bond
D. Comparable in strength to covalent bond.

A

C. Comparable in strength to hydrogen bond

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6
Q

How does cAMP regulate glycogenolysis and glycogenesis?

A

Simultaneously activates phosphorylase and deactivates Glycogen synthase.

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7
Q

Cytochrome which is soluble and readily extractable from the mitochondrial membrane.

A. Cytochrome A
B. Cytochrome C
C. Cytochrome B
D. Cytochrome aa3

A

B. Cytochrome C

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8
Q

Process/Step that produces FADH2

A

Succinate to Fumarate

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9
Q

Fill in the missing substances in the following electron transport chain sequence reaction.

A

FMNH2; 2Fe(II)SP; CoQH2

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10
Q

Which of the following does not occur in RBCs?

A. Beta oxidation of Fatty Acids
B. PPP
C. Glycolysis
D. Fatty acid synthesis

A

A. Beta oxidation of Fatty Acids

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11
Q

Which of the following is an example of inhibitor for the complex III in ETC?

A. Cyanide
B. Antimycin A
C. Hydrogen Sulfide
D. Barbiturates

A

B. Antimycin A

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12
Q
  1. The Px was diagnosed having 2,4- Dinitrophenyl poisoning. (Dinitrophenol- example of uncouplers)

A. Inhibition of Complex I
B. Inhibition of Complex IV
C. Increased permeability of inner mitochondrial membrane to protons
D. Blocking the flow of protons thru ATP synthase

A

C. Increased permeability of inner mitochondrial membrane to protons

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13
Q

Prosthetic Group of Peroxidases

A

Protoheme

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14
Q
  1. Which statement is true about BMI? It is computed as:

A. Kg/cm2
B. Cm2/Kg
C. lb/m2
D. Kg/m2

A

D. Kg/m2

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15
Q

Vitamin needed in succinyl dehydrogenase

A

Riboflavin

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16
Q
  1. Pompe disease- What enzyme determined in the latter test?
A

Acid Alpha Glucosidase

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17
Q

Process if you eat a carbohydrate rich meal and excess ________ is taken away from blood and stored in tissues via _________.

A

Glucose, Glycogenesis

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18
Q
  1. Protein phosphatase-1 catalyzes?

A. Dephosphorylation of phosphorylase a
B. Dephosphorylation of phosphorylase b
C. Dephosphorylation of Glycogen Synthase A
D. Phosphorylation of phosphorylase b

A

A. Dephosphorylation of phosphorylase a

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19
Q
  1. Greatest source of High Energy Phosphate

A. TCA
B. Oxidative Phosphorylation
C. Glycolysis
D. PPP

A

B. Oxidative Phosphorylation

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20
Q
  1. The system is at equilibrium and no net change takes place:

A. ΔG is zero
B. ΔG is positive
C. ΔG is negative

A

A. ΔG is zero

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21
Q
  1. Isoenzyme present in the liver that increases the concentration of G6P as the concentration of glucose increases

A. PEP Carboxylase
B. Pyruvate Synthase
C. Hexokinase

A

C. Hexokinase

22
Q

DM type 2

A

Impaired sensitivity of tissues to insulin action

23
Q

Linkage between Glucose units catalyzed by Glycogen Synthase:

A. Alpha 1-6
B. Beta 1-4
C. Alpha 1-4

A

C. Alpha 1-4

24
Q

Rate Limiting step in Glycogenolysis

A

Glycogen phosphorylase

25
Q

Insulin response

A

Vesicles containing GLUT4 fuse with plasma membrane

26
Q

Cofactor of COA:

A. Riboflavin
B. Niacin
C. Thiamine
D. Pantothenic Acid

A

D. Pantothenic Acid

27
Q
  1. Intermediate carrier of electron from acyl COA dehydrogenase to respiratory chain

A. NAD linked dehydrogenase
B. FAD linked Dehydrogenase
C. Electron Transport Flavoprotein

A

C. Electron Transport Flavoprotein

28
Q

2FADH2 produces how many ATP?

A. 1.5 mol ATP
B. 2.5 mol ATP
C. 3 mol ATP
D. 5 mol ATP

A

C. 3 mol ATP

29
Q

Final acceptor of electron in Electron Transport Chain

A

Oxygen

30
Q

Which part of the cycle uses magnesium?

A

Oxalosuccinate decarboxylation to A-ketoglutarate

31
Q

Non-essential amino acids are:

A. Supplied in the diet because the body cannot synthesize it on its own
B. Supplied via transamination within the body

A

B. Supplied via transamination within the body

32
Q

Removal of Hydrogen. Oxygen as hydrogen acceptor

A

Oxidase

33
Q
  1. Physical activity increases metabolic rate by how many percent?

A. 20%-30%
B. 30%-40%
C. 40%-50%
D. 50%-60%

A

C. 40%-50%

34
Q

State where respiration increases:

A

State 3
(increased respiration occurs in state 3 and 5, state 5 wala sa choices. Resting state is State 4.)

Notes:

-Conditions limiting the rate of respiration:
State 1- Availability of ADP & substrate.
State2 – Availability of Substrate only.
State 3- Capacity of respiratory chain itself
State 4- Availability of ADP only
State 5- Availability of 02

35
Q

Dielectric constant of H20

A

78.5

36
Q

Site of G6P activity:

A. Mitochondria
B. Cell Membrane
C. ER
D. Cytoplasm

A

D. Cytoplasm

37
Q

In malate transport, due to this compound’s impermeability, it needs to bind with glutamate to form aspartate.

A. A-ketoglutarate
B. Oxaloacetate
C. Malate
D. Glycerophosphate

A

B. Oxaloacetate

38
Q

True of amylopectin

A. Linear
B. Linked by Alpha-1,6
C. Branches every 10-12 glucose units
D. Linked by Alpha-1,4

A

B. Linked by Alpha-1,6

39
Q

Brain metabolizes ketone bodies to meet _______ of its energy requirement while the rest is supplied by glucose.

A. 10%
B. 20%
C. 30%
D. 40%

A

B. 20%

40
Q

Active glycogen synthase

A

Dephosphorylated

41
Q

Primary compensation of Metabolic Alkalosis

A

Increase CO2

42
Q

Arsenic poisoning

A

Inhibit Succinyl COA formation

accumulation: of A-Ketoglutarate

43
Q

Ketogenic Amino Acid

A. Leucine
B. Isoleucine
C. Phenyl
D. Tyrosine

A

A. Leucine

44
Q

Px has Rhabdomyolysis, high Creatine Phosphokinase;
Tested negative for phosphofructokinase (substrate used sa test is Fructose-6-phosphate) but tested positive when the substrate used was Fructose-6-biphosphate

A

Tarui

45
Q

Glycogenin

A

Forms glycogen primer

46
Q

Gives rise to both Acetyl COA and intermediates that can be used for Gluconeogenesis.

A

Tyrosine

47
Q

Which is true about phosphatase 1?

A

It is inhibited by inhibitor-1, which is activated after it is phosphorylated by cAMP-dependent kinase

48
Q

Glucose-1-phosphate attaches with what to form the active nucleotide UDPG1c?

A

Uridine triphosphate

49
Q

DM type 1

A

Impaired synthesis of Insulin

50
Q

Energy needed to break the hydrogen bond between water:

A. 3.5
B. 4.5
C. 5.3
D. 5.4

A

B. 4.5

  • Energy requirements to break bonds of H20:
  • 4.5 Kcal/mol= hydrogen bond between water molecules
  • 110Kcal/mol= Covalent bond of O-H within the H20 molecule
51
Q

(Case) Indicative of Glycogen Storage Disease type III. Liver biopsy results should show:

A

D. Accumulation of characteristic branched polysaccharide.

BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam (16 decks)

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