MIDTERMS EVALS 2 (2023) Topic/s: Glycoproteins, Hormone Action, Membrane Structure, Muscle and Cytoskeleton Flashcards
First intracellular signal discovered in
mammalian cells
cAMP
Glucocorticoid directly binds to p65 subunit
of NF-kb and inhibits its activation
TRUE OR FALLS
TRUE
High energy conformation
Myosin-ADP-Pi complex
Inhibits F-actin-myosin interaction
Troponin I
Uses JAK/STAT pathway
Growth hormone
Pingpong mechanism is reversible
TRUE OR FALLS
TRUE
Not true about Smooth muscle
Sarcomere is aligned
Absence of dynein will result in the following except: A. Situs inversus totalis B. Male sterility C. Muscle dystrophy D. Immobile cilia and flagella
C. Muscle dystrophy
Stimulate Adenylyl Cyclase
ADH
Compound that terminates the activity
of cAMP
Phosphodiesterase
Effect of Phosphodiesterase
Decreases cAMP levels
Calmodulin
Binds 4 Ca
Attachment of P. falciparum is mediated by what glycoprotein? A. O-linked B. N-linked C. GPI-linked
C. GPI-linked
DNA transfection
A. Endocytosis
B. Exocytosis
A. Endocytosis
The relax phase of muscle contraction A. Actin head become accessible B. S-1 head of myosin hydrolyze ATP C. Inorganic phosphate is released D. Intercellular levels of ATP drops
B. S-1 head of myosin hydrolyze ATP
Effect of nitroglycerin
Smooth muscle relaxation and vasodilation
Na+K+ pump, 3 Na pumped outside
plasma membrane through?
A. Phosphorylation
B. Dephosphorylation
A. Phosphorylation
True regarding group I hormones
Longer duration of action
Group II hormone is characterized by
Rapid response
Reuptake of macromolecules where there is a finite number of receptors in the plasma membrane. A. IPhagocytosis B. Absorptive pinocytosis C fluid phase pinocytosis D exocytosis
B. Absorptive pinocytosis
True about glucocorticoids A. Receptor is found at the nucleus B. Assoc of hormone causes attachment of corepressor = activation C. Receptor is bound by HSP90 D. NOTA
C. Receptor is bound by HSP90
This is responsible for the negative charge of mucins A. Presence of intermolecular noncovalent bonds B. Presence of proteases C. Presence of NeuAc and Sulphate
C. Presence of NeuAc and Sulphate
Multinucleated cell responsible for bone
resorption?
Osteoclast
Has a glycerol backbone
Phosphoglyceride
Which of the statements regarding peripheral membrane protein is true? A. Reacts extensively with hydrophobic core B. Released from the hydrophilic region through salt solutions with high ionic content C. Requires use of detergent D. Usually globular
B. Released from the hydrophilic region
through salt solutions with high ionic
content
Filaments found in eukaryotic cells except A. Microfilaments B. Microtubules C. Intermediate Filaments D. Macrofilament
D. Macrofilament
Common pentasaccharide of N-linked
glycoproteins
Man3GlcNAc2
Promotes release of calcium from intracellular stores in ER A. IP3 B. DAG C. Both D. None
A. IP3
Not O-linked
Asn-GlcNAc
Cholera toxin
Modifies a-subunit
Major intracellular ions except: A. K+ B. Mg+ C. HCO3- D. PO4
C. HCO3-
Enzymatic marker for endoplasmic reticulum
Glucose-6-phosphatase
Specialized exoplasmic area rich in
sphingolipids, cholesterol and protein
Lipid raft
Area in epithelial cell just below the apical
region which protects from diffusion of
macromolecules
Tight junction
Structure that permits direct transfer of
molecules from one cell to another
Gap junctions
Ion channel opens via binding of molecule
to a receptor
Ligand gated
Movement of glucose in the apical surface
Symport
Allows glucose that accumulates in the
cell to move across the basolateral membrane
into the ECF
Uniport
Strong preference for Dol-P-P Glc-
NAc2Man9Glc3 and is also innibited by tunicamycin
Oligosaccharide:protein transferase
All of the following are true, except:
A. The sarcomere is the region between two
Z lines
B.??
C. Glycogen, ATP, Phosphocreatine are
stored in the sarcolemma
D. ..bisected by the dense and narrow Z line
C. Glycogen, ATP, Phosphocreatine are
stored in the sarcolemma
Effect of atriopeptins
A. Increase cGMP
B. Inhibit guanylyl cyclase
C. Diuretic
A. Increase cGMP
Unsaturated FA tail bind to which carbon
atom
Carbon 2
A disease in a-dystroglycan which protrudes
in the membrane
Congenital muscular dystrophy
Influenza virus
NeuAc
True statement regarding thyroid hormone
Association of hormone to receptor results
in the dissociation of the co-repressor
Minimizes the hydrophilic characteristic of the peptide bond? A. Alpha helical structure B. Beta helical structure C.(micro sign) helical structure D. € helical structur
A. Alpha helical structure
Movement of water through water channels A. Abc transporter B. Aquaporins C. P transporter D. Water transporter
B. Aquaporins
Decreased pH during sleep and RBC
lysis
Paroxysmal Nocturnal Hemaglobinuria
Dolichol PP deficiency
Congenital disorder of glycosylation type
1
Unique to striated muscles except A. Troponin B. Tropomyosin C. ATP D. Calsequestrin
A. Troponin
Chondrodysplacia gene mutation A. Type 1 collagen B. Type 2 collagen C. Fibroblast growth factor receptor D. Both type 2 and fibroblast growth factor receptor
D. Both type 2 and fibroblast growth factor
receptor
Mutation of UDP-Fucose transporter
Leukocyte Adhesion Defect
Relaxation phase
Hydrolysis of ATP
Primary sugar found both in O-linked
and N-linked glycoproteins?
N-Acetylneuramic acid
