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BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam > MIDTERMS EVALS 2 (2023) Topic/s: Glycoproteins, Hormone Action, Membrane Structure, Muscle and Cytoskeleton > Flashcards

MIDTERMS EVALS 2 (2023) Topic/s: Glycoproteins, Hormone Action, Membrane Structure, Muscle and Cytoskeleton Flashcards

1
Q

First intracellular signal discovered in

mammalian cells

A

cAMP

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2
Q

Glucocorticoid directly binds to p65 subunit
of NF-kb and inhibits its activation
TRUE OR FALLS

A

TRUE

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3
Q

High energy conformation

A

Myosin-ADP-Pi complex

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4
Q

Inhibits F-actin-myosin interaction

A

Troponin I

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5
Q

Uses JAK/STAT pathway

A

Growth hormone

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6
Q

Pingpong mechanism is reversible

TRUE OR FALLS

A

TRUE

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7
Q

Not true about Smooth muscle

A

Sarcomere is aligned

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8
Q 
Absence of dynein will result in the following
except:
A. Situs inversus totalis
B. Male sterility
C. Muscle dystrophy
D. Immobile cilia and flagella
A

C. Muscle dystrophy

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9
Q

Stimulate Adenylyl Cyclase

A

ADH

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10
Q

Compound that terminates the activity

of cAMP

A

Phosphodiesterase

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11
Q

Effect of Phosphodiesterase

A

Decreases cAMP levels

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12
Q

Calmodulin

A

Binds 4 Ca

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13
Q 
Attachment of P. falciparum is mediated
by what glycoprotein?
A. O-linked
B. N-linked
C. GPI-linked
A

C. GPI-linked

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14
Q

DNA transfection
A. Endocytosis
B. Exocytosis

A

A. Endocytosis

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15
Q 
The relax phase of muscle contraction 
A. Actin head become accessible
B. S-1 head of myosin hydrolyze ATP
C. Inorganic phosphate is released
D. Intercellular levels of ATP drops
A

B. S-1 head of myosin hydrolyze ATP

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16
Q

Effect of nitroglycerin

A

Smooth muscle relaxation and vasodilation

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17
Q

Na+K+ pump, 3 Na pumped outside
plasma membrane through?
A. Phosphorylation
B. Dephosphorylation

A

A. Phosphorylation

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18
Q

True regarding group I hormones

A

Longer duration of action

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19
Q

Group II hormone is characterized by

A

Rapid response

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20
Q 
Reuptake of macromolecules where
there is a finite number of receptors in the
plasma membrane.
A. IPhagocytosis
B. Absorptive pinocytosis
C fluid phase pinocytosis
D exocytosis
A

B. Absorptive pinocytosis

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21
Q 
True about glucocorticoids 
A. Receptor is found at the nucleus
B. Assoc of hormone causes attachment of
corepressor = activation
C. Receptor is bound by HSP90
D. NOTA
A

C. Receptor is bound by HSP90

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22
Q 
This is responsible for the negative
charge of mucins
A. Presence of intermolecular noncovalent
bonds
B. Presence of proteases
C. Presence of NeuAc and Sulphate
A

C. Presence of NeuAc and Sulphate

23
Q

Multinucleated cell responsible for bone

resorption?

A

Osteoclast

24
Q

Has a glycerol backbone

A

Phosphoglyceride

25
Q 
Which of the statements regarding peripheral
membrane protein is true?
A. Reacts extensively with hydrophobic
core
B. Released from the hydrophilic region
through salt solutions with high ionic
content
C. Requires use of detergent
D. Usually globular
A

B. Released from the hydrophilic region
through salt solutions with high ionic
content

26
Q 
Filaments found in eukaryotic cells except
A. Microfilaments
B. Microtubules
C. Intermediate Filaments
D. Macrofilament
A

D. Macrofilament

27
Q

Common pentasaccharide of N-linked

glycoproteins

A

Man3GlcNAc2

28
Q 
Promotes release of calcium from intracellular
stores in ER
A. IP3
B. DAG
C. Both
D. None
A

A. IP3

29
Q

Not O-linked

A

Asn-GlcNAc

30
Q

Cholera toxin

A

Modifies a-subunit

31
Q 
Major intracellular ions except: 
A. K+
B. Mg+
C. HCO3-
D. PO4
A

C. HCO3-

32
Q

Enzymatic marker for endoplasmic reticulum

A

Glucose-6-phosphatase

33
Q

Specialized exoplasmic area rich in

sphingolipids, cholesterol and protein

A

Lipid raft

34
Q

Area in epithelial cell just below the apical
region which protects from diffusion of
macromolecules

A

Tight junction

35
Q

Structure that permits direct transfer of

molecules from one cell to another

A

Gap junctions

36
Q

Ion channel opens via binding of molecule

to a receptor

A

Ligand gated

37
Q

Movement of glucose in the apical surface

A

Symport

38
Q

Allows glucose that accumulates in the
cell to move across the basolateral membrane
into the ECF

A

Uniport

39
Q

Strong preference for Dol-P-P Glc-

NAc2Man9Glc3 and is also innibited by tunicamycin

A

Oligosaccharide:protein transferase

40
Q

All of the following are true, except:
A. The sarcomere is the region between two
Z lines
B.??
C. Glycogen, ATP, Phosphocreatine are
stored in the sarcolemma
D. ..bisected by the dense and narrow Z line

A

C. Glycogen, ATP, Phosphocreatine are

stored in the sarcolemma

41
Q

Effect of atriopeptins
A. Increase cGMP
B. Inhibit guanylyl cyclase
C. Diuretic

A

A. Increase cGMP

42
Q

Unsaturated FA tail bind to which carbon

atom

A

Carbon 2

43
Q

A disease in a-dystroglycan which protrudes

in the membrane

A

Congenital muscular dystrophy

44
Q

Influenza virus

A

NeuAc

45
Q

True statement regarding thyroid hormone

A

Association of hormone to receptor results

in the dissociation of the co-repressor

46
Q 
Minimizes the hydrophilic characteristic
of the peptide bond?
A. Alpha helical structure
B. Beta helical structure
C.(micro sign) helical structure
D. € helical structur
A

A. Alpha helical structure

47
Q 
Movement of water through water
channels
A. Abc transporter
B. Aquaporins
C. P transporter
D. Water transporter
A

B. Aquaporins

48
Q

Decreased pH during sleep and RBC

lysis

A

Paroxysmal Nocturnal Hemaglobinuria

49
Q

Dolichol PP deficiency

A

Congenital disorder of glycosylation type

1

50
Q 
Unique to striated muscles except 
A. Troponin
B. Tropomyosin
C. ATP
D. Calsequestrin
A

A. Troponin

51
Q 
Chondrodysplacia gene mutation 
A. Type 1 collagen
B. Type 2 collagen
C. Fibroblast growth factor receptor
D. Both type 2 and fibroblast growth factor
receptor
A

D. Both type 2 and fibroblast growth factor

receptor

52
Q

Mutation of UDP-Fucose transporter

A

Leukocyte Adhesion Defect

53
Q

Relaxation phase

A

Hydrolysis of ATP

54
Q

Primary sugar found both in O-linked

and N-linked glycoproteins?

A

N-Acetylneuramic acid

BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam (16 decks)

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