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BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam > MIDTERMS EVALS 1 (2023) Topic/s: GLUCONEOGENESIS, PPP, GLYCOLYSIS, ECM > Flashcards

MIDTERMS EVALS 1 (2023) Topic/s: GLUCONEOGENESIS, PPP, GLYCOLYSIS, ECM Flashcards

1
Q

Most potent activator of

phosphofructokinase known to date

A

Fructose-2,6-biphosphate

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2
Q

Long chains of disaccharides

A

Proteoglycans

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3
Q

Cardinal principle in collagen

biosynthesis

A

Self-assembly

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4
Q 
Which enzyme needs thiamine
pyrophosphate as a cofactor in carrying
out its function in transferring 2 carbon
atom in pentose sugar?
A. Transketolase
B. Pyruvate dehydrogenase
C. Transaldolase
D. Malate dehydrogenase
A

A. Transketolase

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5
Q

Aldolase catalyzes the interconversion

of fructose-1,6-biphoaphate with

A

Dihydroxyacetone phosphate and G3P

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6
Q

Glucokinase and hexokinase differ in

that

A

Hexokinase has a lower Km for glucose

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7
Q

The role of NADPH in antioxidant
reactions
A. It is a source of reducing electrons in
the reaction catalysed by glutathione
reductase
B. It is a direct source of electrons for
reducing hydrogen peroxide
C. It is involved in the reaction catalysed by
glutathione peroxidase
D. If NADPH levels fall, glutathione can
chemically detoxify hydrogen peroxide

A

A. It is a source of reducing electrons in
the reaction catalysed by glutathione
reductase

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8
Q

Hypermobility of joints and

hyperextensibility of skin

A

Ehlers-danlos syndrome

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9
Q

Arsenic poisoning can be explained by

A

Competition with inorganic phosphate as

substrate for G3P dehydrogenase

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10
Q

True of elastin

A

Highly soluble

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11
Q

Glycoprotein with repeating I, II and II
organized into functional domains
consist of Arg-Gly-Asp sequence

A

Fibronectin

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12
Q

Needed by glutathione peroxidase

A

Selenium

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13
Q 
Glycosaminoglycan who has a critical
role in corneal transparency
A. Hyaluronic acid
B. Chondroitin sulphate
C. Karatan sulphate I
D. Keratan sulphate II
E. Heparin
A

D. Keratan sulphate II

Pwede both keratan sulphates I and II
pero ang sa choices kay KARATAN not
KERATAN

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14
Q

Fermentation of D-glucose with baker’s

yeast

A

Pyruvate dehydrogenase

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15
Q 
During fasting, which of the following
would tend to increase the flux of
gluconeogenesis
A. Concentration of free amino acids
decreases
B. Concentration of cAMP decreases
C. Fructose-2,6-biphosphate decreases
D. Phsophoenolpyruvate carboxykinase is
initiated
A

C. Fructose-2,6-biphosphate decreases

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16
Q

True of transaldolase

A

Converts ribulose-5-phosphate to
glyceraldehyde-3-phosphate and
fructose-6-phosphate

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17
Q

Inhibited by fluoride

A

Enolase

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18
Q

Major type of collagen in skin and bones

A

Type I collagen

19
Q

True of cartilage except A. Avascular
B. Type II collagen is the principal protein
in cartilage
C. Exhibits rapid and continuous
turnover
D. Obtains nutrients from the synovial fluid

A

C. Exhibits rapid and continuous

turnover

20
Q 
What happens after fasting
A. Decreased adenylate kinase
B. Decreased cAMP
C. Increased phosphofructokinase
D. Induce phosphoenolpyruvate
carboxykinase
A

D. Induce phosphoenolpyruvate

carboxykinase

21
Q 
14 yr-old girl presents with fatigue, loss
of weight from fasting for 3 months
because she wants to be a skinny
legend. She has normal fasting glucose
levels, elevated ketone, and leukopenia.
What caused her hypoglycaemia
A. Impaired insulin secretion
B. Enhanced glucagon secretion
C. Impaired hydrolysis of liver glycogen
D. Impaired conversion of amino acids
to glucose
A

D. Impaired conversion of amino acids

to glucose

22
Q

Lactate from muscles becomes available
again in circulation through the process
of

A

Cori cycle

23
Q

Reaction catalysed by pyruvate kinase

A

Example of substrate level

phosphorylation

24
Q 
Non-equilibrium reaction in glycolysis 
A. Hexokinase
B. Phosphofructokinase
C. Pyruvate kinase
D. All of the Above
A

D. All of the Above

25
Q 
Glucoronic pathway in man chiefly
functions to
A. Furnish metabolic intermediates for fat
and protein synthesis
B. Oxidation of glucose chuchu
C. ---
D. Synthesis of vitamin C
A

way answer lloyd tabang

26
Q

Unique to gluconeogenesis

A

OAA to PEP

27
Q 
When fatty acid beta oxidation
predominates in the liver,
mitochondrial pyruvate is most likely to
be
A. Carboxylated into…
B. Oxidatively carboxylated into acetyl coa
to enter ketogenesis
C. Reduced to lactate to enter
gluconeogenesis
D. Oxidatively carboxylated into acetyl
coa to enter krebs cycle
E. Carboxylated into
A

D. Oxidatively carboxylated into acetyl

coa to enter krebs cycle

28
Q 
All are characteristics of achondroplasia
except
A. Autosomal dominant trait
B. Normal trunk size
C. Short limbs
D. Microcephaly
E. Most common in dwarfism
A

D. Microcephaly

29
Q 
Major component of glomeruli and
other basal laminae
A. Collagen
B. Fibrillin
C. Laminin
A

C. Laminin

30
Q

Bone

A

Type I collagen and hydroxyapatite

31
Q

ATP of aerobic and anaerobic glycolysis

A

32, 2

32
Q 
All GAG contains sulphate group except 
A. Chondroitin
B. Hyaluronic acid
C. Heparin
D. Dermatan
E. Keratin
A

B. Hyaluronic acid

33
Q

Unidirectional reaction

A

Hexokinase, phosphofructokinase,

pyruvate kinase

34
Q

Precursor of collagen

A

Preprocollagen

35
Q

Deficient in scurvy

A

Lysyl hydroxylase

36
Q

False about elastin

A

19 genetic types (Only 1)

37
Q

Polypeptide chains with elongated

cruciform shape

A

Laminin

38
Q

Cannot synthesize ascorbate due to lack

of this enzyme

A

L-gluconolactone oxidase

39
Q 
During myocardial infarction, oxygen
supply to an area of the heart is
decreased that caused cardiac myocytes
to undergo anaerobic metabolism.
Under this condition, which would be
activated by increasing intracellular
AMP?
A

Phosphofructokinase-1

40
Q 
Carboxylation of pyruvate to
oxaloacetate requires
A. Biotin
B. Niacin
C. Thiamine
D. Riboflavin
A

A. Biotin

41
Q

Enzymes associated with irreversible

steps in glycolysis

A

Hexokinase, phosphofructokinase,

pyruvate kinase

42
Q

Oxaloacetate produced from pyruvate
through pyruvate carboxylase will be
introduced to gluconeogenesis through

A

Oxaloacetate will be reduced to malate to
be exported to the cytoplasm the
converted to phosphoenolpyruvate

43
Q

Well-fed state

A

↓ glucagon, ↑ insulin = ↑ fructose 2, 6

biphosphate = ↑glycolysis

BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam (16 decks)

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