PREFI - LIPID CHEM

Question 1

Of the following lipoproteins, which one is inversely related to the incidence of
coronary atherosclerosis?
a. chylomicron
b. high density lipoprotein
c. intermediate lipoprotein
d. low density lipoprotein
e. very low density lipoprotein

Answer 1

b. high density lipoprotein

Question 2

In the shuttle of mitochondrial acetyl coenzyme A to the cytosol for fatty acid
synthesis, in which step generates NADPH?
a. oxaloacetate + acetyl coenzyme A  citrate
b. oxaloacetate -> malate
c. malate -> pyruvate
d. pyruvate -> oxaloacetate
e. citrate _ coenzyme A -> oxaloacetate _ acetyl coenzyme A

Answer 2

c. malate -> pyruvate

Question 3

The lipoprotein that serves to transport triacylglycerol from the liver to the
different extrahepatic tissues:
a. chylomicrons
b. high density lipoproteins
c. intermediate density lipoproteins
d. low density lipoproteins
e. very low density lipoproteins

Answer 3

e. very low density lipoproteins

Question 4

Which of the following apolipoproteins serves as inhibitor of

lecithin: cholesterol acyltransferase (LCAT)?
a. apolipoprotein A-II
b. apolipoprotein A-IV
c. apolipoprotein B-48
d. apolipoprotein C-I
e. apolipoprotein C-II

Answer 4

a. apolipoprotein A-II

Question 5

In the following steps in ketone bodies metabolism, NADH is generated in:

a. acetoacetate  acetone
b. acetoacetate  beta hydroxybutyrate
c. acetoacetyl coenzyme A + acetyl coenzyme A  HMG coenzyme A
d. beta hydroxybutyrate  acetoacetate
e. HMG coenzyme A  acetoacetate + acetyl coenzyme A

Answer 5

d. beta hydroxybutyrate  acetoacetate

Question 6

Human body synthesize cholesterol de novo from acetyl coenzyme A.
Cholesterol synthesis occurs in which of the following organelles?
a. cytosol
b. endoplasmic reticulum
c. golgi apparatus
d. mitochondria
e. ribosomes

Answer 6

a. cytosol

Question 7

Among the following apolipoproteins, which one serves as lipid transfer
protein?
a. apolipoprotein A-IV
b. apolipoprotein B-100
c. apolipoprotein C-III
d. apolipoprotein D
e. apolipoprotein E

Answer 7

d. apolipoprotein D

Question 8

Among the following conditions, which one is characterized by pathologic
accumulation of galactocerebroside in the affected tissues.
a. Farber’s Disease
b. Fabry’s Disease
c. Gaucher’s Disease
d. Krabbe’s Disease
e. Metachromatic Leukodystrophy

Answer 8

d. Krabbe’s Disease

Question 9

Which of the lipoproteins has the highest triacylglycerol content?

a. chylomicrons
b. high density lipoproteins
c. intermediate density lipoproteins
d. low density lipoproteins
e. very low density lipoproteins

Answer 9

a. chylomicrons

Question 10

Ketone bodies maybe synthesized from fatty acids by which of the following
organs or cells?
a. skeletal muscle
b. liver
c. kidney
d. erythrocytes
e. brain

Answer 10

b. liver

Question 11

Spontaneous decarboxylation of acetoacetate results in the formation of:

a. acetone
b. acetyl coenzyme A
c. 3-hydroxybutyrate
d. malonyl coenzyme A
e. propionate

Answer 11

a. acetone

Question 12

Which of the lipoproteins has the highest total lipid content?

a. chylomicrons
b. high density lipoproteins
c. intermediate density lipoproteins
d. low density lipoproteins

Answer 12

a. chylomicrons

Question 13

The major site of fatty acid synthesis:

a. mammary gland
b. liver
c. kidney
d. brain
e. adipose tissue

Answer 13

b. liver

Question 14

Of the following lipoproteins, which one is elevated in Type I Hyperlipidemia?

a. chylomicrons
b. high density lipoproteins
c. intermediate density lipoproteins
d. low density lipoproteins
e. very low density lipoproteins

Answer 14

a. chylomicrons

Question 15

Of the following lipids, which one is accumulated is tissues of patient with
Tay-Sach’s Disease?
a. ceramide trihexoside
b. galactocerebroside sulfate
c. ganglioside
d. glucoceberoside
e. sphingomyelin

Answer 15

c. ganglioside

Question 16

In the separation of plasma lipoprotein by electrophoresis on agarose gel, which fraction is located closest to the negative pole?

a. chylomicrons
b. HDL
c. LDL
d. VLDL
e. Triglycerides

Answer 16

a. chylomicrons

Question 17

During uncontrolled diabetes mellitus or starvation, which of the following organs utilizes ketone bodies as much as 75% for its energy substrate?

a. Heart
b. Brain
c. Kidney
d. Skeletal muscles

Answer 17

b. Brain

Question 18

In the biosynthesis of fatty acids, what is the compound that transports the acetate group out of the mitochondria into the cytoplasm

a. pyruvate
b. malate
c. citrate
d. acyl carnitine
e. acyl coenzyme A

Answer 18

c. citrate

Question 19

Activation of medium chain and short fatty acids occurs in the

a. Ribosomes
b. Mitochondrial matrix
c. Golgi apparatus
d. Endoplasmic reticulum
e. Cytosol

Answer 19

b. Mitochondrial matrix

Question 20

The committed step in fatty acid synthesis is the formation of

a. Acetyl coenzyme A
b. Acetyl acyl carrier protein
c. Malonyl coenzyme A
d. Malonyl acyl carrier protein

Answer 20

c. Malonyl coenzyme A