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BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam > PREFI EVALS 1&2 (2023) Topic/s: LIPIDS, BLOOD COAG, RBC & WBC > Flashcards

PREFI EVALS 1&2 (2023) Topic/s: LIPIDS, BLOOD COAG, RBC & WBC Flashcards

1
Q

ATP in red blood cells are produced in a process

called?

A

Glycolysis

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2
Q 
Primary hemostasis is made possible by the
following:
A. Platelets
B. Fibrinogen (?)
C. Coagulation Factors
D. All of the above
A

A. Platelets

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3
Q

Produces NADH

A

G6PD

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4
Q 
Most important inhibitor of thrombin? 
A. Antithrombin
B. Heparin cofactor II
C. Antitrypsin
D. NOTA
A

A. Antithrombin

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5
Q

End product of Fatty Acid Synthesis

A

Palmitate

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6
Q

Which of the statement is true?
A. Stem cells produce all types of cells
B. Pluripotent stem cells differentiate to
produce cells of closely related family
C. Stem cell are also classified as adult or
embryonic, the latter of which are more
limited in their capacity to differentiate
D. -

A

A. Stem cells produce all types of cells

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7
Q

Monounsaturated Fatty Acid

a. Stearic
b. Linoleic
c. Oleic
d. Alpha-linoleic

A

c. Oleic

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8
Q

Phospholipid component of inner mitochondrial

membrane

A

Cardiolipin

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9
Q

Vitamin K dependent

A

IX, X, VII, II and protein C

1972

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10
Q

T/F. hemophilia is an X linked disorder

A

DRIVE TRUE hahahahhahahah

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11
Q

Steps for fibrin mesh formation

A

Fibrinogen – monomer – polymer – cross link with

factor VIII

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12
Q

Double helical filament of F actin

A

Band 5

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13
Q

Initial and controlling step

A

Malonyl CoA

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14
Q 
Which does not act on plasmin directly? 
A. TAFIa
B. A-antiplasmin
C. Plasminogen Activator inhibitor
D. NOTA
A

way answer lloyd tabang

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15
Q

Cofactor required for acetyl CoA to malonyl CoA

A

Biotin

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16
Q

T/F. Glucagon activates Acetyl CoA decarboxylase

by dephosphorylation.

A

FALSE

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17
Q

Glucose enters RBC via facilitated diffusion, which
is mediated by a special transporter called?
A. Glut 11
B. Glucose permease
C. Glucose premease
D. Glut 12

A

B. Glucose permease

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18
Q 
Richest source of cholesterol 
A. Egg yolk
B. Ice cream
C. Juice in tetrapack
D. Milk
A

A. Egg yolk

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19
Q

T/F. thrombin has both procoagulant and

anticoagulant functions.

A

my TRUE my knees my shoulder my head

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20
Q 
What enzyme enables absorption of waste CO2 
A. Carbonic acidase
B. Carbonic anhydrase
C. Carbonic hydratase
D. Carbonic permease
A

B. Carbonic anhydrase

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21
Q 
Most abundant RBC membrane cytoskeleton
 A. Band 3
B. Band 5
C. Spectrin
D. Ankyrin
A

C. Spectrin

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22
Q 
Promote platelet activation 
A. Thrombin
B. ADP
C. Thromboxane A2
D. AOTA
A

D. AOTA

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23
Q 
Which is correctly matched? 
A. APTT – intrinsic
B. PT – extrinsic
C. Both
D. Neither
A

C. Both

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24
Q 
The principal building block of Fatty Acid 
A. Malonyl CoA
B. Acetyl CoA
C. HMG CoA
D. Oxaloacetate
E. Acyl CoA
A

B. Acetyl CoA

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25
Q

In the shuttle of mitochondrial acetyl CoA to the
cytosol for free fatty acid synthesis, which step
generates NADPH?

A

Malate to Pyruvate

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26
Q 
Aspirin 
A. Inhibit cyclooxygenase
B. Induces platelet aggregation
C. Damage endothelium
D. Promote fibrinolysis
A

A. Inhibit cyclooxygenase

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27
Q 
Coumarin inhibits: 
A. Factor
B. Factor II
C. VI
D. VIII
A

B. Factor II

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28
Q

Storage form of Fatty Acid

A

TAG

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29
Q

Correct pairing of drug and antidote: A. Coumarin – vitamin K
B. Heparin – protamine
C. Neither
D. Both

A

D. Both

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30
Q

True about G6PD deficiency
A. –
B. –
C. Decrease activity of G6PDH

A

way answer

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31
Q 
Patient had MI and is given tissue plasminogen
activator. What is the action of this?
A. Prevent extrinsic pathway
B. Inhibit thrombin
C. Enhances fibrinolysis
D. Inhibit platelet aggregation
A

C. Enhances fibrinolysis

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32
Q

Which of the ff leukocytes defend against large
parasites by immobilizing them with the web
formed by strand of chromosomal dna?
A. Neutrophil and macrophage
B. Neutrophil and basophil
C. Neutrophil and eosinophil
D. Neutrophil and monocyte

A

C. Neutrophil and eosinophil

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33
Q

True of Von Willebrand factor
A. Secreted by endothelial cell and platelet
B. Stabilizes factor 8
C. Promotes platelet adhesion at site of vessel
injury
D. All statements are true

A

D. All statements are true

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34
Q

Step that produces NADPH

A

Malate to pyruvate

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35
Q

T/F. Intrinsic and Extrinsic pathways both

activate factor X

A

true

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36
Q

Activates Acetyl CoA carboxylase

A

Citrate`

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37
Q 
Contains sialic acid which is found in the highest
concentration in the brain?
A. Gangliosides
B. Glucosylceramides
C. Galactoceramides
D. AOTA
A

A. Gangliosides

38
Q 
Inhibits acetyl CoA carboxylase 
A. ADP something
B. Glucosylation
C. Phosphorylation
D. Fanesylation
A

C. Phosphorylation

39
Q 
Venous thrombosis 
A. Protein C deficient
B. Protein S deficient
C. Antithrombin deficient
D. AOTA
A

D. AOTA

40
Q

What ABO type contains the most H substance?

A

Type O

41
Q

Fatty acids with high molecular weight

monohydric alcohol

A

Waxes

42
Q

Lecithin

A

Phosphatidylcholine

43
Q

Blood Types A and B

A

IgM

44
Q

Sugar for antigen B

A

Galactose

45
Q

Sugar for antigen A

A

N-acetylgalactosamine

46
Q

Found in coconut oils

A

Lauric

47
Q

Allosteric effector of hemoglobin that regulates
the affinity of hemoglobin for oxygen that
facilitates the release of oxygen to the tissues:

A

2,3 BPG

48
Q 
Not intrinsic hemolytic anemia 
A. PNH
B. Enzymopathies
C. Hypersplenism
D. Abnormal Hb
A

C. Hypersplenism

49
Q 
Which is the most common bleeding disorder? 
A. –
B. –
C. vWF disease
D. AOTA
A

C. vWF disease

50
Q

Naturally occurring antibodies

A

Formed without antigenic stimulation

51
Q

Humoral immunity

A

Lymphocytes

52
Q

T/F. change in shape of platelets indicates

activation.

A

true

53
Q 
Granulocytes, EXCEPT? 
A. Eosinophil
B. Neutropil
C. Monocyte
D. Basophil
A

C. Monocyte

54
Q

Fatty acid synthesis occurs in

A

Cytosol

55
Q

Major glycolipid in the brain

A

Galactosylceramides

56
Q

Galactocerebroside composition

A

Galactose + FA + Sphingosine

57
Q

Action of leukotrienes, EXCEPT?

A

Induce sleep

58
Q

T/F. Insulin and thyroid hormones increase HMG

reductase activity

A

TRUE

59
Q

Inihibits Phospholipase A2 from forming

eicosanoids

A

Steroids

60
Q

Site of action of NSAIDS

A

Prostaglandin cyclooxygenase

61
Q

Each cycle of beta oxidation produces

A

1 NADH, 1FADH2, 1 acetyl CoA

62
Q

Oxidation of FA with odd number of carboxyl

yields

A

Acetyl CoA + Propionyl

63
Q

End product of Squalene

A

Lanosterol

64
Q

Most abundant lipid in blood plasma

A

Cholysteryl Esters

65
Q

T/F. Elevated levels of cholesterol in LDL and
VLDL is related with atherosclerosis while high
HDL have a protective effect.

A

true

66
Q

Most active plasma lipid

A

Unesterified FA

67
Q

Added to diacylglycerol DAG to form TAG

A

Acyl CoA

68
Q 
Action of lipoprotein lipase 
A. hydrolyzes TAG of plasma lipoprotein to
supply tissues 
B. –
C. –
D. ----- supply tissues with amino acids
E. NOTA
A 
A. hydrolyzes TAG of plasma lipoprotein to
supply tissues (?)
69
Q

Excess cholesterol is secreted as

A

Bile Salt

70
Q

T/F. A decrease of 100ml/mg dietary alcohol =

decrease approximately 0.13mmol/L of serum

A

true

71
Q 
True about TAG synthesis in intestinal musoca 
A. Requires phosphatidic acid as intermediate
B. Uses 2 monoacylglycerol from
triglyceride digestion
C. Uses alpha glycerophosphate from
dihydroxyacetone phosphate reduction
D. A & B
E. A & C
A

C. Uses alpha glycerophosphate from

dihydroxyacetone phosphate reduction

72
Q

Starting material for ketogensis

A

Acetoacetyl CoA

73
Q

Uncommon in carnitine deficiency
A. Preterm infants
B. Hemodialysis pt
C. Febrile seizures

A

C. Febrile seizures

74
Q

Can form arachidonic Acid

A

Linoleic Acid

75
Q

Enzyme found in outer mitochondrial membrane

A

Carnitine palmitoyltransferase I (CPT-I)

76
Q

Prostanoids
A. Leukotrienes, lipoxins
B. Thromboxanes , prostacyclin

A

B. Thromboxanes , prostacyclin

77
Q

Acetylation of both PGHS 1 & 2

A

Aspirin

78
Q

One mole of palmitoyl will undergo ___ rounds if
beta oxidation and will produce ____ acetyl CoA
A. 7,7
B. 7,8
C. 16,7
D. 16,8

A

B. 7,8

79
Q

Closely associated with beta 100 lipoprotein A. LDL

B. HDL

A

A. LDL

80
Q 
Not true about chylomicrons 
A. Found in chyle
B. Derived from intestinal absorption of TAG
C. –
D. Predominantly cholesterol
A

D. Predominantly cholesterol

81
Q

Cofactor for lipoprotein lipase (LPL)

A

APO CII

82
Q

Cofactor for LCAT

A

APO AI

83
Q

Net ATP generated per mol of palmitate

A

106 ATP

84
Q

Condensation of 6 IPP requires how many ATP?

A

18 ATP

85
Q

Major lipoprotein present in HDL

A

Lipoprotein A

86
Q

Cholesterol synthesis occurs in?

A

Cytoplasm

87
Q 
Final stage in VLDL metabolism
A. Chylomicron
B. LDL
C. HDL
D. AOTA
A

B. LDL

88
Q

Initial substrate in cholesterol synthesis

A

Acetyl CoA

89
Q

Chemical formula for cholesterol

A

C27H45OH

90
Q 
Stimulates release of arachidonic acid from
membrane phospholipid
A. Epinephrine
B. Thrombin
C. Bradykinin
D. AOTA
A

D. AOTA

BIOCHEMISTRY - 1st Year 1st Sem Comprehensive Exam (16 decks)

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