PREFI EVALS 1&2 (2023) Topic/s: LIPIDS, BLOOD COAG, RBC & WBC Flashcards
ATP in red blood cells are produced in a process
called?
Glycolysis
Primary hemostasis is made possible by the following: A. Platelets B. Fibrinogen (?) C. Coagulation Factors D. All of the above
A. Platelets
Produces NADH
G6PD
Most important inhibitor of thrombin? A. Antithrombin B. Heparin cofactor II C. Antitrypsin D. NOTA
A. Antithrombin
End product of Fatty Acid Synthesis
Palmitate
Which of the statement is true?
A. Stem cells produce all types of cells
B. Pluripotent stem cells differentiate to
produce cells of closely related family
C. Stem cell are also classified as adult or
embryonic, the latter of which are more
limited in their capacity to differentiate
D. -
A. Stem cells produce all types of cells
Monounsaturated Fatty Acid
a. Stearic
b. Linoleic
c. Oleic
d. Alpha-linoleic
c. Oleic
Phospholipid component of inner mitochondrial
membrane
Cardiolipin
Vitamin K dependent
IX, X, VII, II and protein C
1972
T/F. hemophilia is an X linked disorder
DRIVE TRUE hahahahhahahah
Steps for fibrin mesh formation
Fibrinogen – monomer – polymer – cross link with
factor VIII
Double helical filament of F actin
Band 5
Initial and controlling step
Malonyl CoA
Which does not act on plasmin directly? A. TAFIa B. A-antiplasmin C. Plasminogen Activator inhibitor D. NOTA
way answer lloyd tabang
Cofactor required for acetyl CoA to malonyl CoA
Biotin
T/F. Glucagon activates Acetyl CoA decarboxylase
by dephosphorylation.
FALSE
Glucose enters RBC via facilitated diffusion, which
is mediated by a special transporter called?
A. Glut 11
B. Glucose permease
C. Glucose premease
D. Glut 12
B. Glucose permease
Richest source of cholesterol A. Egg yolk B. Ice cream C. Juice in tetrapack D. Milk
A. Egg yolk
T/F. thrombin has both procoagulant and
anticoagulant functions.
my TRUE my knees my shoulder my head
What enzyme enables absorption of waste CO2 A. Carbonic acidase B. Carbonic anhydrase C. Carbonic hydratase D. Carbonic permease
B. Carbonic anhydrase
Most abundant RBC membrane cytoskeleton A. Band 3 B. Band 5 C. Spectrin D. Ankyrin
C. Spectrin
Promote platelet activation A. Thrombin B. ADP C. Thromboxane A2 D. AOTA
D. AOTA
Which is correctly matched? A. APTT – intrinsic B. PT – extrinsic C. Both D. Neither
C. Both
The principal building block of Fatty Acid A. Malonyl CoA B. Acetyl CoA C. HMG CoA D. Oxaloacetate E. Acyl CoA
B. Acetyl CoA
In the shuttle of mitochondrial acetyl CoA to the
cytosol for free fatty acid synthesis, which step
generates NADPH?
Malate to Pyruvate
Aspirin A. Inhibit cyclooxygenase B. Induces platelet aggregation C. Damage endothelium D. Promote fibrinolysis
A. Inhibit cyclooxygenase
Coumarin inhibits: A. Factor B. Factor II C. VI D. VIII
B. Factor II
Storage form of Fatty Acid
TAG
Correct pairing of drug and antidote: A. Coumarin – vitamin K
B. Heparin – protamine
C. Neither
D. Both
D. Both
True about G6PD deficiency
A. –
B. –
C. Decrease activity of G6PDH
way answer
Patient had MI and is given tissue plasminogen activator. What is the action of this? A. Prevent extrinsic pathway B. Inhibit thrombin C. Enhances fibrinolysis D. Inhibit platelet aggregation
C. Enhances fibrinolysis
Which of the ff leukocytes defend against large
parasites by immobilizing them with the web
formed by strand of chromosomal dna?
A. Neutrophil and macrophage
B. Neutrophil and basophil
C. Neutrophil and eosinophil
D. Neutrophil and monocyte
C. Neutrophil and eosinophil
True of Von Willebrand factor
A. Secreted by endothelial cell and platelet
B. Stabilizes factor 8
C. Promotes platelet adhesion at site of vessel
injury
D. All statements are true
D. All statements are true
Step that produces NADPH
Malate to pyruvate
T/F. Intrinsic and Extrinsic pathways both
activate factor X
true
Activates Acetyl CoA carboxylase
Citrate`
Contains sialic acid which is found in the highest concentration in the brain? A. Gangliosides B. Glucosylceramides C. Galactoceramides D. AOTA
A. Gangliosides
Inhibits acetyl CoA carboxylase A. ADP something B. Glucosylation C. Phosphorylation D. Fanesylation
C. Phosphorylation
Venous thrombosis A. Protein C deficient B. Protein S deficient C. Antithrombin deficient D. AOTA
D. AOTA
What ABO type contains the most H substance?
Type O
Fatty acids with high molecular weight
monohydric alcohol
Waxes
Lecithin
Phosphatidylcholine
Blood Types A and B
IgM
Sugar for antigen B
Galactose
Sugar for antigen A
N-acetylgalactosamine
Found in coconut oils
Lauric
Allosteric effector of hemoglobin that regulates
the affinity of hemoglobin for oxygen that
facilitates the release of oxygen to the tissues:
2,3 BPG
Not intrinsic hemolytic anemia A. PNH B. Enzymopathies C. Hypersplenism D. Abnormal Hb
C. Hypersplenism
Which is the most common bleeding disorder? A. – B. – C. vWF disease D. AOTA
C. vWF disease
Naturally occurring antibodies
Formed without antigenic stimulation
Humoral immunity
Lymphocytes
T/F. change in shape of platelets indicates
activation.
true
Granulocytes, EXCEPT? A. Eosinophil B. Neutropil C. Monocyte D. Basophil
C. Monocyte
Fatty acid synthesis occurs in
Cytosol
Major glycolipid in the brain
Galactosylceramides
Galactocerebroside composition
Galactose + FA + Sphingosine
Action of leukotrienes, EXCEPT?
Induce sleep
T/F. Insulin and thyroid hormones increase HMG
reductase activity
TRUE
Inihibits Phospholipase A2 from forming
eicosanoids
Steroids
Site of action of NSAIDS
Prostaglandin cyclooxygenase
Each cycle of beta oxidation produces
1 NADH, 1FADH2, 1 acetyl CoA
Oxidation of FA with odd number of carboxyl
yields
Acetyl CoA + Propionyl
End product of Squalene
Lanosterol
Most abundant lipid in blood plasma
Cholysteryl Esters
T/F. Elevated levels of cholesterol in LDL and
VLDL is related with atherosclerosis while high
HDL have a protective effect.
true
Most active plasma lipid
Unesterified FA
Added to diacylglycerol DAG to form TAG
Acyl CoA
Action of lipoprotein lipase A. hydrolyzes TAG of plasma lipoprotein to supply tissues B. – C. – D. ----- supply tissues with amino acids E. NOTA
A. hydrolyzes TAG of plasma lipoprotein to supply tissues (?)
Excess cholesterol is secreted as
Bile Salt
T/F. A decrease of 100ml/mg dietary alcohol =
decrease approximately 0.13mmol/L of serum
true
True about TAG synthesis in intestinal musoca A. Requires phosphatidic acid as intermediate B. Uses 2 monoacylglycerol from triglyceride digestion C. Uses alpha glycerophosphate from dihydroxyacetone phosphate reduction D. A & B E. A & C
C. Uses alpha glycerophosphate from
dihydroxyacetone phosphate reduction
Starting material for ketogensis
Acetoacetyl CoA
Uncommon in carnitine deficiency
A. Preterm infants
B. Hemodialysis pt
C. Febrile seizures
C. Febrile seizures
Can form arachidonic Acid
Linoleic Acid
Enzyme found in outer mitochondrial membrane
Carnitine palmitoyltransferase I (CPT-I)
Prostanoids
A. Leukotrienes, lipoxins
B. Thromboxanes , prostacyclin
B. Thromboxanes , prostacyclin
Acetylation of both PGHS 1 & 2
Aspirin
One mole of palmitoyl will undergo ___ rounds if
beta oxidation and will produce ____ acetyl CoA
A. 7,7
B. 7,8
C. 16,7
D. 16,8
B. 7,8
Closely associated with beta 100 lipoprotein A. LDL
B. HDL
A. LDL
Not true about chylomicrons A. Found in chyle B. Derived from intestinal absorption of TAG C. – D. Predominantly cholesterol
D. Predominantly cholesterol
Cofactor for lipoprotein lipase (LPL)
APO CII
Cofactor for LCAT
APO AI
Net ATP generated per mol of palmitate
106 ATP
Condensation of 6 IPP requires how many ATP?
18 ATP
Major lipoprotein present in HDL
Lipoprotein A
Cholesterol synthesis occurs in?
Cytoplasm
Final stage in VLDL metabolism A. Chylomicron B. LDL C. HDL D. AOTA
B. LDL
Initial substrate in cholesterol synthesis
Acetyl CoA
Chemical formula for cholesterol
C27H45OH
Stimulates release of arachidonic acid from membrane phospholipid A. Epinephrine B. Thrombin C. Bradykinin D. AOTA
D. AOTA
