PRELIM: EPITHELIAL TISSUE Flashcards
is a tissue in which cells are bound
tightly together structurally and functionally to form a sheetlike or tubular structure with little extracellular material between the cells.
EPITHELIUM
facing the sheet’s free surface
APICAL SIDE
facing a basement membrane and
underlying connective tissue
BASAL SIDE
pinocytosis of material at the
apical side
TRANSCYTOSIS
at the basolateral side
EXOCYTOSIS
a thin extracellular layer of specialized proteins, usually having two parts: a basal lamina and a more fibrous reticular lamina
BASEMENT MEMBRANE
2 parts of Basement membrane:
BASAL LAMINA
RETICULAR LAMINA
is a thin meshwork of type IV collagen and laminin produced by the epithelial cells
BASAL LAMINA
contains type III collagen and anchoring of VIII collagen, all secreted by cells of the immediately adjacent connective tissue
RETICULAR LAMINA
FUNCTIONS OF BASEMEMENT MEMBRANE:
attach epithelia to connective tissue
regulate (filter) substances passing from connective tissue into epithelia
provide a guide or scaffold during tissue regeneration after injury
compartmentalize epithelial cells from other tissues
INTERCELLULAR JUNCTIONS
3 MAJOR TYPES
TIGHT OR OCCLUDING JUNCTIONS
ADHERENT OR ANCHORING JUNCTIONS
GAP OR COMMUNICATING JUNCTIONS
TIGHT OR OCCLUDING JUNCTIONS
Claudin and occludin surround the apical ends of the cells and prevent paracellular passage of substances (between the cells.)
ADHERENT OR ANCHORING JUNCTIONS
- formed by interacting proteins of the cadherin family
- points of strong attachment holding together cells of the epithelium
encircle epithelial cells just below their tight junctions or scattered
Zonula adherens
desmos (binding) soma (body) disc shaped structures
Desmosomes
composed of transmembrane integrins attach cells to proteins of the basal lamina
Hemidesmosomes
- Mediate intercellular communication rather than adhesion or occlusion between cells
- Connexins form hexameric complexes called connexons
GAP OR COMMUNICATING JUNCTIONS