POST LAB EXPERIMENT 9 Flashcards
Primary defenses against treponemal invasion are
intact skin and mucous membranes
Skin is penetrated- (?) play a key role in
the immune response
T cells and macrophages
Reported in Medical Literature as early as
1495
-discovered that syphilis was caused by a spirochete bacteria Treponema pallidum
1905
Causative agent:
Treponema pallidum subspecies pallidum
Primary mode of infection:
Sexual transmission
Other modes:
Congenital infection, Parenteral exposure
10 to 90 days after infection
Primary Stage Syphilis
Chancre
Primary Stage Syphilis
painless, solitary lesion characterized by raised well defined borders
Chancre
a painless chancre develops at the site where the bacteria entered the body.
Primary Stage Syphilis
A person is highly contagious during the
Primary Stage Syphilis
The chancre lasts (?) and heals without treatment
28-42 days
Systemic dissemination of organisms occurs
Secondary Syphilis
Secondary Syphilis
Observed (?) after primary chancre
1 to 2 months
Generalized lymphadenopathy
Secondary Syphilis
A rash often develops all over the body, including palms of the hands and the soles of the feet
Condylomata lata
The rash usually heals without scarring in
2-12 wk.
Open sores may be present on mucous membranes and may contain pus flat lesions resembling warts in moist areas of the body (e.g., around the anus or vagina)
Condylomata lata
These lesions do not reflect areas of inoculation but appear to be caused by hematogenous dissemination of spirochetes.
Condylomata lata
Symptoms can include nervous system abnormalities.
Secondary Syphilis
Disappearance of secondary syphilis
Latent stage Syphilis
Stage that lacks clinical symptom
Latent stage Syphilis
: less than 1 year duration
Early latent stage
: More than 1 year of infection
Late latent stage
If untreated, an infected person will progress to the (hidden) stage of syphilis with no symptoms
Latent stage Syphilis
The latent period may be as brief as (?) or range from (?)
1 yr
5-20 yr.
A person is contagious during the early part of the latent stage and may be contagious during the latent period.
Latent stage Syphilis
Gummas
Late (Tertiary) stage syphilis
– localized areas of granulomatous inflammation
Gummas
Bones, skin and subcutaneous tissue
Gummas
May heal with scarring or remain destructive areas of chronic inflammation
Late (Tertiary) stage syphilis
Most destructive stage of syphilis
Late (Tertiary) stage syphilis
If untreated, the tertiary stage may begin as early as 1 yr
after infection or at any time during a person’s lifetime.
Late (Tertiary) stage syphilis
A person may never experience this stage of the illness.
Late (Tertiary) stage syphilis
symptoms depend on the complications that develop—gummata
Late (Tertiary) stage syphilis
large sores inside the body or on the skin, cardiovascular syphilis, or neurosyphilis.
gummata
Degeneration of the lower spinal cord
Tabes Dorsalis
General paresis
Tabes Dorsalis
Chronic progressive dementia
Tabes Dorsalis
Seen in immunodeficient patients
Neurosyphilis
May occur any time after primary stage
Neurosyphilis
malaise
Secondary Syphilis
fever
Secondary Syphilis
pharyngitis
Secondary Syphilis
rash in the skin and mucous membranes
Secondary Syphilis
Condylomata lata
Secondary Syphilis
