POST LAB EXPERIMENT 11

Question 1

• A pathologic process in which an extremely high fever is a characteristic manifestation.

Answer 1

febrile disease

Question 2

• It is a group of microbial infections characterized by fever and production of antibodies known as
febrile agglutinins

Answer 2

febrile disease

Question 3

Enumerate and describe other types of febrile diseases

Answer 3

 Lyme Disease
 Paratyphoid fever
 Rocky Mountain spotted fever
 Tularemia
 Q Fever

Question 4

 Borrelia burgdorferi

Answer 4

febrile disease Lyme Disease

Question 5

 Lyme disease

Answer 5

febrile disease

Question 6

MOT:

Answer 6

spread by the bite of infected ticks of the genus Ixodes.

Question 7

• Erythema chronicum migrans

Answer 7

Stage 1: Early infection

Question 8

• Spirochetes spread
  hematogenously to body tissues by way of bloodstream and disease may take various forms.

Answer 8

Stage 2: Dissemination stage

Question 9

• Symptoms include muscle and joint pain, fatigue, chills and fever, headache, swollen lymph nodes, secondary annular skin lesions.

Answer 9

Stage 2: Dissemination stage

Question 10

• Commonly involves intermittent
  episodes of joint pain which is
  often misdiagnosed as arthritis.

Answer 10

Stage 3: Chronic disseminated

Question 11

• Some common clinical manifestations of this stage can include meningitis, Bell’s palsy, cardiac involvement, migratory pain to joints, tendons, muscle and bone.

Answer 11

Stage 3: Chronic disseminated

Question 12

The typical clinical presentation after inoculation of (?) through abrasions in the skin or by arthropod bites includes the development of a lesion at the site and progresses to an ulcer lymph node adjacent to the site of inoculation become enlarged and often necrotic.

Answer 12

F. tularensis

Question 13

Once the organism enters the bloodstream, patients become systemically ill with high temperature, chills, headache, and generalized aching.

Answer 13

tularensis

Question 14

Clinical manifestations of infection with (?) range from mild and self-limiting to fatal

Question 15

• Symptoms occur approximately 7 days after a tick bite.

Answer 15

Rocky Mountain spotted fever

Question 16

• A rash, which starts on the hands and feet and proceeds to the trunk, appears in 3 to 5 days after the beginning of other symptoms.

Answer 16

Rocky Mountain spotted fever

Question 17

• The organism infects endothelial cells, causing an increase in vascular permeability and focal hemorrhages

Answer 17

Rocky Mountain spotted fever

Question 18

Current serological assays for rickettsia antibodies are organism-specific and include

Answer 18

indirect fluorescent assays (IFA), microimmunofluorescent assays (micro-IF), immunoperoxidase assays (IPA), ELISA, and immunoblot assays (IBA)

Question 19

require the whole bacterium as the reagent

Answer 19

1. IFA and IPA

Question 20

are currently considered the gold standard for detecting rickettsial antibodies

Answer 20

The IFA test and the micro-IF

Question 21

OX-19 and OX-2: ?

Answer 21

Proteus vulgaris

Question 22

OX-K: ?

Answer 22

Proteus mirabilis

Question 23

(?) is useful for identifying several rickettsia diseases, such as murine typhus and Q fever.

Answer 23

The Weil-Felix test

Question 24

Titers of 160 are usually considered significant.

Answer 24

The Weil-Felix test

Question 25

which uses a light microscope instead of a fluorescent microscope to read the slides

Answer 25

IPA

Question 26

Testing by both of these methods can detect significant titers of antibodies in Rocky Mountain spotted fever by the second week of infection.

Answer 26

IFA
IPA

Question 27

appears in 60% to 80% of infected individuals 2-32 days after being bitten by infected tick.

Answer 27

Erythema chronicum migrans

Question 28

use rickettsial antigens adsorbed onto a solid phase or nitrocellulose membrane.

Answer 28

2. ELISA and IBA

Question 29

They include glandular , ulceroglandular oculoglandular, oropharyngeal, systemic, and pneumonic forms.

Answer 29

F. tularensis

Question 30

has a sensitivity and specificity similar to that of IFA

Answer 30

IPA

Question 31

These include fever, severe headache, malaise, and myalgia, accompanied by nausea, vomiting, abdominal pain, and sometimes a cough.

Answer 31

Rocky Mountain spotted fever

Question 32

(IFA)

Answer 32

indirect fluorescent assays

Question 33

(micro-IF)

Answer 33

microimmunofluorescent assays

Question 34

(IPA)

Answer 34

immunoperoxidase assays

Question 35

(IBA)

Answer 35

immunoblot assays