Population Genetics

Question 1

Polymorphisms

Answer 1

Single nucleotide substitution, insertion, or deletion

1/1000 in population

Question 2

Hardy Weinburg Assumptions

Answer 2

Random Mating
No migration
No fluctuations in allele frequency
No selection

Question 3

Reasons for Genetic Variation

Answer 3

Natural Selection
Genetic Drift
Founder Effect
Bottleneck Effect 
Inbreeding

Question 4

Allele A in population

Answer 4

2p(AB)+p^2(AA)

Question 5

Allele B in population

Answer 5

2q(AB)+q^2 (BB)

Question 6

Calculating risk of phenotypic inheritance

Answer 6

Chance mother carrying x Chance father carrying x chance child showing phenotype

Child can vary based on mode of inheritance

Question 7

Coefficient of inbreeding

Answer 7

1/8 chance of shared alleles, so it’s 1/16

Question 8

Prior probability

Answer 8

Probability that father is or is not a carrier

Question 9

Conditional probability

Answer 9

Other family considerations

Question 10

Joint probability

Answer 10

Prior X Conditional

Question 11

Posterior probability

Answer 11

Ratio of the joint probability to the sum of all other joint probabilities