Cell Division Flashcards
1
Q
G1 Cdk
A
Puts cell past restriction point
2
Q
G1/S Cdk
A
Commits the cell to replication
3
Q
S Cdk
A
Initiates replication
Binds and dissociates ORC by phosphorylation Cdc6
This also prevents re-replication
4
Q
M Cdk
A
Promotes mitosis
Activated by Cdc25 and CAK
Inhibited by Wee1
5
Q
APC
A
Ub’s M-CyclinCdk
6
Q
CKI
A
P27 protein that inhibits cyclin-Cdk
7
Q
E2F
A
TF for S-cyclin
8
Q
Rb Protein
A
Inhibits E2F
9
Q
p53 at g1 damage checkpoint
A
Expresses CKI, which then binds Cyclin-Cdk
