ECM Flashcards
1
Q
Structure of collagen
A
Triple a helix in pattern of Gly-X-Y, assembled outside of cell I-bone, tendons, ligaments --(90%) II-cartilage III-skin IX- used to associate type II fibrils
2
Q
Other collagen Types
A
IV- sheet like network under cells
VII- anchoring network
XVII-collagen anchoring filaments
3
Q
Elastin
A
Assembled outside of cell
Fibrillin polymer
4
Q
Glyocosaminoglycans
A
Bind water and resist compression
5
Q
Proteoglycans
A
Mechanical support
6
Q
Aggrecan
A
Cartilage
7
Q
Perlecan
A
Uses heparin sulfate in Basel lamina
8
Q
Syndecan
A
Fibroblast and epithelial cell surface
Example of connection between ECM and signaling pathways
9
Q
Integrins
A
Bind actin cytoskeleton and organize signaling molecules
10
Q
Integrin activation
A
Signal receptor binds with Ligands
Causes conformational change in integrin to active state
B2- lymphocyte
B3- platelet
