Cell-Cell Communication

Question 1

Tetrode in

Answer 1

Na channel blocker

Question 2

Nuclear Steroid Hormone Ligands

Answer 2

Androgens
Glucocorticoids 
Mineralcorticoids 
Estrogen 
Progesterone

Question 3

Steroid hormone related diseases

Answer 3

Cushings
Addisons
70% of breast cancer

Question 4

Estrogen receptor antagonist

Answer 4

Tamoxifen

Question 5

Grb

Answer 5

G receptor binder
Binds to protein kinase receptor
Attached to GEF

Question 6

Ras

Answer 6

Cell signal protein

Involved in kinase pathways (MAPKKK)

Question 7

GAP’s

Answer 7

Stimulate GTPase activity in a G protein

Question 8

GEF’s

Answer 8

Stimulate the change from GDP to GTP

Question 9

Rab

Answer 9

Trafficking of membrane vesicles

Question 10

Ran

Answer 10

Membrane/cytoplasm traffic

Question 11

Rac family

Answer 11

Actin cytoskeleton

Question 12

Ras and Cancer

Answer 12

Gly-12 gly-13 or gay-61
Mutations often cause GTP to remain bound
Stays active indefinitely

Question 13

7-a-helix receptors

Answer 13

Signaling causes GEF activation of large G proteins

Question 14

G protein Ga

Answer 14

Gs-a: activates adenylate cyclase
Gs-i: inhibits adenylate cyclase
Gq-a: activates phospholipidase

Question 15

Desentization of 7-a-helix

Answer 15

B-adrenergic 7-a-helix (binds epi/norepi)
when ligand bound, becomes substrate for BARK, which adds P
Then bound by B arrestin- cannot bind Gs anymore