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FINAL Biomedical Sciences > Cell Biology > Flashcards

Cell Biology Flashcards

1
Q

PMP cell stabilization

A

Actin, Spectrin

Hereditary spherocytosis- mutation in Spectrin causes RBC’s to become spherical and burst

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2
Q

Membrane Protein Functions

A

Transporters
Anchors
Receptors
Enzymes

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3
Q

Glycocalyx

A

Glycolipids
Glycoproteins
Proteoglycans

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4
Q

Smooth ER Functions

A

Lipid, steroid biosynthesis
Detoxification
Drug metabolism
Calcium storage

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5
Q

Rough ER Functions

A

Proteins that will be exported from the cell, secretary proteins
Lysosomal proteins
Membrane proteins

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6
Q

Golgi things to know

A

Cis>medial>trans transport using vesicles

Secratory vesicles bus from trans Golgi Network (TGN)

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7
Q

Receptor mediated endocytosis

A

Uses a coated pit-uses PM to engulf and break off something extracellularly and bring it inside
Endoscopes-distinct organelles, vesicles bringing stuff in from outside

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8
Q

Lysosomes

A

Vesicle pH maintained by a pump

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9
Q

Phosphatidyl Serine

A

The negative one

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10
Q

Curare

A

Toxin that blocks Ach

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11
Q

Carrier Transport

A

Faster than simple diffusion

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12
Q

P type pump

A

ATP driven

Small ions

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13
Q

ABC pump

A

ATP driven

Small molecules

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14
Q

Intermediate filaments

A

Used for receptor-nucleus signaling
Basic structure is a coiled coil tetramer
No directionality= no transport

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15
Q

Actin Filaments

A

+ end is fast growing; - end is slow growing
Helical structure made of globule monomers
Uses ATP for building, but doesn’t need it

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16
Q

Microtubules

A

AB tubulin monomers
Oriented and builds like actin
Uses GTP to build
Used for cilia, flagella, centrioles

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17
Q

Primary cilium

A

Non motile; sensory

Used in hh pathway

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18
Q

+ tip proteins

A

Associate with the growing end to prevent catastrophe

Associate with kinetochore

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19
Q

Phalloidin

A

Binds and stabilizes actin filaments

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20
Q

Taxol

A

Binds and stabilizes micro tubules

GOOD FOR ANTI-CANCER

21
Q

Colchicine

A

Depolymerizes micro tubules

22
Q

ATP 2/3 complex

A

Facilitates actin branching for cellular migration

23
Q

Listeria Bacteria

A

Hijacks Arp 2/3 mechanism and uses it to move around cell like a comet

24
Q

Myosin

A

+ directed on actin

Myosin II and V

25
Q

Kinesin

A

+ end directed on micro tubules

26
Q

Dynein

A
  • end directed on micro tubules

Found in ciliary and flagellar arms for beating

27
Q

Types of Myosin

A

I-micro villus
II-contraction, microfilments
V-Carries cargo

28
Q

Ran GTP in nucleus

A

Binds AB importin and dissociates it from the target protein

Dissociates from AB by GAP activity

29
Q

SRP

A

Signal Recognition Particle

Binds ctyosolic ribosome at N terminus and directs it to

30
Q

Glycosylation

A

Addition of sugar polymer to tag protein and act as recognition through certain post translational modifications

31
Q

ARF

A

Used for COP-I vesicle formation

32
Q

Sar

A

Used for formation of COP-II vesicles

33
Q

COP II Transport

A

ER to Cis Golgi

34
Q

COP I transport

A

Retrograde

35
Q

Cathrin Transport

A

Anything to do with endosomes

36
Q

Rab Proteins

A

Used for vesicle targeting and recognition

37
Q

V snares

A

Hook onto the vesicle

38
Q

T snares

A

Hook onto the target (Golgi, endosome, etc)

39
Q

Trans Golgi

A

Where protein segregation and sorting begins

40
Q

Adapting

A

Bind both clathrins and cargo receptors

If damaged, the whole system goes to hell

41
Q

Tight junction

A

Occulin, claudin

At very top of cell to prevent leaks between cells

42
Q

Belt junctions

A

Cadherins
Bind actin on cytoskeleton
Zona adherins

43
Q

Spot desmosomes

A

Macula adherins
Cadherins with keratin fibers coming out
Attaches to intermediate filament

44
Q

Hemidesmosome

A

Attaches to basal lamina

Integrin a6b4 and intermediate filaments

45
Q

Focal adhesion

A

Necessary for cell survival, growth, and hemidesmosomes

Integrins and actin

46
Q

Gap junctions

A

Use 6 Connexin molecules

Used in muscle cells for molecular communication

47
Q

Selectins

A

Serve as speed bumps to slow down leukocytes
Activated by calcium binding
Recognizes stuff by carbohydrate recognition domain (CRD)

48
Q

IG superfamily

A

Bind to identical molecules on another cell (trans-homo) or other members of the family (trans-hetero)
T cell interactions, and leukocyte to surface interactions
Help leukocytes to zorp into cells

FINAL Biomedical Sciences (15 decks)

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