Pharmacogenetics Flashcards
1
Q
Cytochrome p450’s
A
Activate/deactivate drugs
Phase 1- addition of hydroxyl
Phase 2- functionalization of hydroxyl group
Responsible for metabolism of 90% of drugs
2
Q
Warfarin
A
Competitive inhibitor for Vitamin K
Blood thinner- prevents clotting
Broken down by CYP’s that add OH groups to make it more soluble
3
Q
Human CYP expression
A
Varies between 2 people
We use different CYP’s at different levels
4
Q
Tolerance
A
The amount of drug that you need to experience an effect
Certain CYP mutations will cause a reduction in tolerance, and therefore a dose reduction
5
Q
Comparing mobilizers
A
Comparing how long it takes to interact with drug Pharmacodynamics Extensive mobilizer -AA Immediate mobilizer- Aa Poor mobilizer- aa
6
Q
100% GWAS
A
Impossible because environment of population is variable
