Mitochondria Flashcards
1
Q
Genes in mtDNA
A
ATP synthase Cytochrome oxidase Cytochrome B NADH dehydrogenase 16/12S rRNA
2
Q
D Loop
A
Site where transcription is controlled
3
Q
Twinkle
A
MtDNA Helicase
4
Q
MtRNA transcription is
A
Polycistronic
5
Q
MtRNA
A
Uncapped
Tiny 5’ UTR
AAA tail is adjacent to STOP
6
Q
High mtDNA mutation rate
A
DNA Pol y is bad at proofreading
No introns
Close to ROS
7
Q
Bottleneck Effect
A
During oogenesis, mt is reduced. If bad ones remain, then only bad ones will exist after replication. This cell will be bad :(
8
Q
Homoplasmy
A
All mt are the same in a cell
9
Q
Random Segregation
A
Fusion and fission will lead to random array of mt and mutant mt in a cell.
10
Q
Threshold effect
A
Amount of ATP needed for cell survival
Higher in more E dependent tissues
More mutations with age, and below this threshold, a bad phenotype is observed
