Polymers of Life 7: Pharmacophores

Question 1

Definition of lead compound

Answer 1

• A chemical compound that has pharmacological or biological activity likely to be therapeutically useful but it structure may need modification
• ( useful but has side effects )

Question 2

Definition of pharmacophore ( in medicines )

Answer 2

• Part of the molecule that binds to the active site

= give the medicine its particular pharmacological affect ( makes it medicinally active )

( different medicines can have the same pharmacophore but have been modified to either make it more affective or have less side-effects )

Question 3

Be able to identify the pharmacophore in different molecule

Answer 3

Look at sheet

Question 4

How/ why different enantiomer affect the effectiveness of a pharmacophore

Answer 4

• One isomer has the correct shape orientation and specificity for the enzyme active site
• The receptor wanna kill is chiral say one item if it’s

Question 5

Give a brief summary of pharmacophores

Answer 5

• can be modified by changing functional groups
• Interact with receptor or active sites by following week interactions
• fit into the receptor site with the correct size, shape, orientation and must form the correct weak interactions
  ( molecular recognition )

Question 6

Definition of asmolecular recognition

Answer 6

Idea that a drug molecule or a substrate fitting into an active site has to be specific with the correct orientation, correct shape, and correct bonds so that it can be catalysed by the active site