Polio Flashcards
3 serotypes of polio
types 1-3
which serotype of polio still exists as a wild strand?
which only exists in vaccines?
Wild: type 1
Vaccine: type 2
2 different polio vaccines and what level of immunity they offer
Salk Vaccine: inactivated polio virus, not lifelong immunization
Sabin Vaccine: live attenuated oral vaccine, lifelong immunity
source of vaccine associated paralytic poliomyelitis
oral polio vaccine(very rare though)
source of circulating vaccine derived poliovirus
mutations in poliovirus type 2
what is polio cause by
enterovirus C
wild type polio virus is still found in which 2 countries
Afghanistan and Pakistan
which polio type is now being used in the global polio oral vaccine campaign
type 2
poliovirus attacks the CNS and localizes where
anterior horn cells of the spinal cord
how is polio transmitted
-through infected saliva droplets
-ingestion of contaminated fecal material
T/F the majority of people who contract polio suffer severe illness and paralysis
FALSE. 95% are asymptomatic
what disease was reffered to as the middle class plague? why?
Polio
-in rural communities polio circulated freely, and infants got natural immunity to it from mothers.
-children living in cleaner areas did not get this, and were first exposed when going to school, and got sick due to lack of immunity
who discovered that polio was contagious
Karl Landsteiner and Erwin Popper
what US president had polio
Franklin D. Roosevelt
who was sister Kenny
a nurse during the polio era who invented mainstream physical therapy
what makes polio a key candidate for eradication
-no animal reservoir
-effective + cheap vaccines
-life-long immunity
-virus cant survive long outside host
T/F out of the 3 serotypes of poliovirus type 1 is the only one that has not been eradicated
TRUE
