Polimiximas Flashcards

1
Q

Mecanismo de las polimiximas

A

Desorganizan la estructura de la membrana celular e inhiben la actividad del lipopolisacarido. Son bactericidas

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2
Q

Nombres de las polimiximas

A
Polimixima B
Polimixima E (colistina)
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3
Q

VA de la polimixima B

A

EV

T

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4
Q

VA de la polimixima E (colistina)

A

EV

IM

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5
Q

VE de las polimiximas

A

R

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6
Q

Cobertura de las polimiximas

A
Bacilos (-)
Bacilos aerobios multiresistentes 
Pseudomonas
Acitenobacter
Enterobacteriaceae
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7
Q

Efectos adversos de las polimiximas

A
Nefrotoxicidad
Bloqueo neuromuscular
Neurotoxicidad
Neuropatia periferica
Hipersensibilidad
Convulsiones (cuando se administra via intratecsl)
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8
Q

Las polimiximas se utilizan en el embarazo?

A

No

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9
Q

Las polimiximas atraviesan la BHE?

A

No

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10
Q

Las polimiximas NO cubren:

A

Proteus
Serratia
Providencia

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