Cloranfenicol Flashcards

1
Q

Mecanismo de accion del cloranfenicol

A

Inhiben la sintesis de proteinas uniendose a la subunidad ribosomal 50s. Son bacterioestaticos

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2
Q

VA del cloranfenicol

A

VO

EV

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3
Q

VE del cloranfenicol

A

H

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4
Q

Cobertura del cloranfenicol

A
Cocos (+)
MRSA
Estreptococo
Cocos (-)
Neisseria
Bacilos (-)
Salmonella. MUY activo
Haemophilus
Anaerobios
Atipicos: coxiella y rickettsia
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5
Q

Efectos adversos del cloranfenicol

A
Anemia aplasica irreversible
Hepatotoxicidad
Sindrome del niño gris en neonatos (ausencia de glucoronil transferasa)
Neuritis optica
Complicaciones tipicas anaerobios
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6
Q

El cloranfenicol se utiliza en embarazo?

A

No

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7
Q

El cloranfenicol atraviesa la BHE?

A

Si

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8
Q

Indicaciones del cloranfenicol

A
Alergia a beta lactamicos
Meningitis B (2da linea)
Neumonia B (2da linea)
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9
Q

Los neumococos resistentes a penicilinas tambien tienen cierta resistencia al cloranfenicol?

A

Si

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10
Q

El cloranfenicol se utiliza combinado con ampicilina?

A

No

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11
Q

El cloranfenicol es el ATB que cubre mayor cantidad de anaerobios distintos?

A

Si

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