Pneumonia Flashcards
What is the basic definition of pneumonia
Infection in the lung
Also known as a respiratory tract infection
Lobar Pneumonia
Involvement of entire lung lobe
Typically is the end result of severe or chronic bronchopneumonia that has spread of one lung segment to another until the entire lung is involved
Double Pneumonia
Involvement of both lungs
Walking Pneumonia
Mild case of pneumonia where the patient remains ambulatory
Often caused by mycoplasma pneumoniae
What are the different causes of pneumonia
Bacteria
Viruses
Fungi,
Protozoa,
Parasites,
TB,
anaerobic organisms,
aspirations
Inhalation of irritating chemical like chlorine
Bronchopneumonia
Patchy pattern of infection limited to segmental bronchi and surrounding lung parenchyma
Usually involves both lungs
Seen more often in lower lobes
polymorphonuclear leukocytes
Will go into the alveoli with bacterial pneumonia in order to clear out the infection
Will not travel into the alveoli for interstitial pneumonia
Interstitial pneumonia
Diffuse and often bilateral inflammation that primarily involves the alveolar septa (separates adjacent alveoli) and the interstitial space
Mycoplasma pneumonia and other viruses cause interstitial pneumonias.
Most interstitial pneumonias cause only minor permanent alveolar damage and usually resolve without consequences.
CURB-65
CURB-65, is used to help predict mortality for CAP and guide where the patient shout be treated
C-Confusion
U-Blood urea >20 mg/dl
R-RR >30
B-Blood pressure with systolic <90 or diastolic <60
65-Is the patient greater than 65
If any of the above questions are answered yes, then it is considered to be one point
1 or 2 risk criteria-outpatients
2 criteria-wards
three or more risk factor should be treated in ICU
The risk factors for the development of HAP and VAP
- Factors that interfere with hosts immunity
- Underlying illness
- Certain interventions (intubation or trach)
- Meds such as sedative and corticosteroids
- Factors the encourage exposure to pathogenic micro-organisms
- Endotracheal or nasogastric tube
- Contaminated equipment
- Prior antibiotic therapy
- Neutralization of gastric pH
Non-ventilated patient mortality risk with pneumonia increased when there is
Bilateral infiltrates
Respiratory Failure
Infection with high risk organism
Ventilated patient mortality risk with pneumonia increased when there is
Infection with high-risk organisms such as P. aeruginosa, Acinetobacter species, and Stenotrophomonas maltophilia
Multisystem organ failure
Nonsurgical diagnosis
Therapy with antacids or histamine-2 (H2)-receptor antagonists
Transfer from another hospital or ward
Renal failure
Prolonged mechanical ventilation
Coma or shock
Inappropriate antibiotic therapy
Hospitalization in a noncardiac ICU
Empiric anti-microbial therapy and Pneumonia
Empiric anti-microbial therapy is used while a definitive microbiologic diagnosis is awaited
Empiric therapy is treatment that is initiated based on the most likely cause of infection when the specific cause is unknown
In ~50% of patient a microbiologic diagnosis has not been made which can be attributed to
Inability for patient to produce sputum
The sputum acquisition is done after antibiotics has been started
There is a failure to perform routine serologic studies in all patients
Many different organisms (viruses and anaerobic bacteria) are not routinely tested for
fomites
Objects capable of transmitting infection through physical contact with them
what is VAP
VAP stands for Ventilator-Associated Pneumonia and is basically pneumonia that develops 48 hours or longer after mechanical ventilation is initiated on a patient.
What are the three most common gram-negative organisms associated with VAP?
(1) Pseudomonas aeruginosa, (2) klebsiella pneumoniae, and (3) E. Coli
What is the most common gram-positive organism associated with VAP?
Methicillin-Resistant Staphylococcus Aureus
What kind of secretions typically does a diagnosed VAP patient have?
Strong smell (purulent)
What fungi can cause VAP in immunocompromised patients?
Aspergillus
What is pneumonia?
Pneumonia is an inflammatory condition of the lungs primarily affecting the alveoli which may fill with fluid and pus. It is an acute infection of the lung parenchyma.
What is the assessment of viral pneumonia?
Low-grade fever, non-productive cough, WBC normal to low elevation, less severe than bacterial.
What can be assessed on patients with bacterial pneumonia?
High fever, productive cough, WBC elevated, chest X-ray show infiltrates more severe.
What medication therapy can be used for pneumonia?
Antibiotics, bronchodilator, and corticosteroids.
What type of pneumonia is frequently undiagnosed?
Nonbacterial Pneumonia.
What are the three key signs of bacterial pneumonia?
Expectoration of yellow sputum, increased white blood cell count, and the presence of fever.
What type of anatomic alteration leads to aspiration pneumonia?
Alveolar consolidation – atelectasis – inflammation of the alveoli.
What term applies to the filling of alveolar spaces as a result of pneumonia?
Effusion.
The expression “walking pneumonia” is generally applied to patients with what type of pneumonia?
Mycoplasma pneumonia
What is the most commonly found bacterial cause of pneumonia?
Streptococcus pneumonia
What are some of the viruses that can cause pneumonia?
Influenza A or B, respiratory syncytial virus, rhinovirus, and coronavirus (SARS, MERSCoA).
What are some of the fungi that can cause pneumonia?
Cryptococcus, histoplasma, coccidioides, aspergillus and mucor.
What are some of the non-infectious etiologies of pneumonia?
Carcinomas, lymphomas, vasculitis, sarcoidosis, heart failure and pulmonary embolism.
What is the problem with pneumonia?
Even with antibiotics, patients with pneumonia have a high morbidity and mortality rates with the highest incidence in 1-4-year-olds or over 65.
What is hospital-acquired pneumonia?
This type of pneumonia is a ventilator associated and health care associated and happens at least 48 hours – 72 hours or more after admission to the hospital.
What is the pathophysiology of pneumonia?
- Trigger inflammatory response-Increase blood flow and vascular permeability
- Neutrophil activation
- Microorganism enter alveoli
- Extotxin produced by bacteria or cell lysis caused by viruses
- Increased vascular permeability
- Macrophage recruitment
What is the inflammatory response?
More neutrophils are activated (cascade effect) resulting to edema of the airways and fluid leaks from the capillaries to the alveoli. This affects normal oxygen transport.
What are the mechanical barriers from a bacterial infection?
Mechanical barriers include air filtration, epiglottis, cough reflex, and mucociliary response; reflex bronchoconstriction; and, secretion of immunoglobulins A and G and alveolar macrophages.
Why is antibiotic therapy beneficial for pneumonia?
Macrophages break down the bacteria and process the debris, lung tissue is allowed to recover and gas exchange returns to normal. They help to result in homeostasis and healing occurs if there are no other complications.
What type of pneumonia is more common in children and young adults?
Viral pneumonia.
What type of pneumonia is more common in adults and elderly?
Strep pneumonia.
What type of pneumonia is commonly found in people with HIV?
Pneumocystic jiroveci (FUNGAL).
What are the most common forms of pneumonia in neonates (0-1 month)?
Group B Strep and HSV.
What is the most common cause of pneumonia in infants (1-6 months)?
Bordetella pertussis and chlamydia trachomatis.
What is the most common cause of pneumonia in children (6 months – 5 years old)?
RSV and influenza.
What is the most common pathogen found on a young, healthy adult contracting pneumonia?
Mycoplasma.
What is the most common cause of pneumonia in older adults?
Strep pneumonia and H. flu.
What chest x-ray finding would indicate that the pneumonia will be difficult to treat and is life threatening?
Lung abscess (pus in the lung).
What are the atelectasis findings on a chest x-ray?
Collapse or incomplete expansion of the lung, loss of volume, Dyspnea or respiratory failure if severe and apex will usually be at the hilum.
What chest x-ray finding is usually associated with empyema (pus in the lung)?
Parapneumonic effusion.
What is a bronchogram on chest x-ray?
Air filled bronchi made visible by opacification of surrounding alveoli and peribronchial cuffing/thickening.
What will you usually see on a CBC with pneumonia?
Leukocytosis and L shift.