Overview

Question 1

What Does it mean for a drug to have a high potency

Answer 1

Means the drug will show its affect at a lower dose

Higher MAC= Lower potency

Question 2

Potency and lipid solubiity

Answer 2

Increase potency occurs when you have an increased lipid solubility

Question 3

Blood Solubility

Answer 3

A decrease in blood solubility mean that the drug will act faster (does not matter the dose)

Increased onset of action with higher solubility

Question 4

blood gas partition coefficent

Answer 4

comparing blood solubility to gas solubility of the gas drug

Question 5

MAC

Answer 5

Measure of potency

Measure of the concentration it take for 50 people to show the effects of the drug this means the the higher the MAC the lower the potency

Question 6

Nitrous Oxide solubility and MAC

Answer 6

Nitrous oxide has a low blood gas partition (low blood solubility) so it will show its affects very rapidly

Nitrous oxide has a high MAC (you need a large amount before you would ever see the affects)

Question 7

Nitrous Oxide Solubility

Answer 7

Because it has such a low solubility in the blood it will not stick around in the blood very fast and will go to the brain very fast (blood does not hold it for long)

Question 8

Diffusion Hypoxia

Answer 8

When we use nitrous oxide it will equliibrate between the brain blood and lungs very fast.

If you turn off the ventilator all of the nitrous oxide will rush back into the lungs in order to be removed from the body, remember it has a low solubility in blood so it will not stay in the blood for long and rather rush back to alveoli

The nitrous oxide in lung will then be decreased the oxygen concentration (opposite of the second gas effect) because the oxygen does not have enough time to equilibrate concnetrations back into the lungs

Question 9

Diffusion Hypoxia Treatment

Answer 9

Ventilate with 100% oxygen