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Hema 2 > Platelet Maturation > Flashcards

Platelet Maturation Flashcards

1
Q

Produced by the brain derived from platelets and endothelial cells

A

Serotonin

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2
Q

Serotonin derived from what

A

Platelet and endothelial cells

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3
Q

NC ration pf megakaryoblast

A

10:1

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4
Q

Multiple nucleoli blue cytoplasm

A

Megakaryoblast

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5
Q

Chromatin become coarse, ieegulaly shape nucleus

A

Promegakaryocyte

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6
Q

NC ratio of promegakaryocyte

A

4:1-7:1

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7
Q

Multiple nuclei no nucleoli

A

Mature megakaryocyte

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8
Q

NC ratio of mature megakaryocyte

A

1:1

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9
Q

Disintegrated cells surrounded by platelets

A

Metamegakaryocyte

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10
Q

Life span of platelets

A

8-11 days

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11
Q

Ration of platelets in circulation

A

2/3

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12
Q

Ratio of platelet in the spleen

A

1/3

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13
Q

Decrease platelets

A

Splenomegaly

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14
Q

Nuclear dibision without cytoplasmic dibision

A

Endomitosis

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15
Q

Thrombopoietin produced by

A

Liver and kidney

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16
Q

Responsible for platelet adhesion and aggregation

A

Peripheral zone

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17
Q

Fxns as the outer surface

A

Glycocalyx

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18
Q

Consist 30 or more gycoprotein

A

Plasma mem

19
Q

3 parts pf peripheral zone

A

Glycocalyx, plasma mem, submembranous area

20
Q

Actin and myosin

A

Microfilaments

21
Q

Consist of that maintains the shape of platelet

A

Microtubules

22
Q

Responsible for clot retraction

A

Thrombostenin

23
Q

Parts of organelle zone

A

Dense granules

Mitochondria, lysosomal granules

24
Q

Fxns as release of granules

A

Open canalicular system

25
Q

Parts of membranous system

A

Dense tubular system and open canalicular system

26
Q

Platelet adherence or expose sub endothelial surface/collagen

A

Adhesion

27
Q

Adhesion occur in the presence of what

A

Von willebrands factor

28
Q

Due to lack of von willebrand factor

A

Von willebrand disease

29
Q

Deficient of gp16

A

Bernard soulier disease/ giant platelet syndrome

30
Q

Acts as von willebrand factor

A

Gp16

31
Q

Morphologic and fucntion changes in platelet

A

Activation

32
Q

Subs that stimulate activation

A

Agonist

33
Q

Stimulate platelet secretion

A

Thromboxane A2

34
Q

Inhibit cyclooxygenase

A

Aspirin

35
Q

Release of grabules

A

Secretion

36
Q

Alpha granule deficiency

A

Gray platelet syndrome
Chediak higashi
Wiskott aldrich syndrome

37
Q

Dense granile deficiency

A

Hermansky pudlak

38
Q

Triad of immunodeficency, casuse thrombocytopenia and eczema

A

Wiskott aldrich syndrome

39
Q

Deficiency of factor V

A

Quebec platelet disorder

40
Q

Platelet attachmemt to each other

A

Aggregation

41
Q

Aggregation requires

A

Fibrinogen and calcium

42
Q

Deficiency of gpIIb

A

Glanzmann thrombosthenia

43
Q

Maturation sequence of megakaryoblast takes about 5 days. Platelet are produced firectly from the megakaryocytes clusters of granules aggregates from platelet

A

Platelet maturation sequence

Hema 2 (10 decks)

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