Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hema 2 > Anemias > Flashcards

Anemias Flashcards

1
Q

Blood picture of AA

A

Normocytic, normochromic
Leucopenia
Thrombocytopenia
Pancytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Causes pf aplastic anemia

A

Ionizng radiation
Tumor of the thymus
Exposure to radicals
Congenital/hereditary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the exposure to radicals

A

Naphthalene, arsenical, benzene, chordane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Congenital and hereditary in aplastic anemia

A

diamond black fan viral hep, oncogenic virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ofi in AA

A

Decreased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Formed due to excessive destruction and shortening of the life span pf the rbc and it can be an acquired or congenital

A

Hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Causes of HA

A

Presence of Ab
Due to toxins
Due to drugs
Due to inherited intracorpuscular anomaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Due to the presence of Ab in HA spec what

A

Hdn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ofi pf HA

A

Incease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Ha is can correlate to

A

Spherocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Includion bodies of HA

A

Howeel jolly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Blood picture of HA

A

High retics
Inc nrbc
Presence of poikilocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

2 main dicision that causes HA

A

Corpuscular defect and extracorpuscular defect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The problem is the rbc itself

A

Intrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Defect in the cell mem

A

Pnh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pnh is previously known as

A

marchiafava micheli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Inclusion bodies in HA under intrinsic

A

Hereditary spherocytosis, achantocytosis, elliptocytosis and zeive syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Defect in intracellular enzyme iclude

A 
Anaerobic glycolysis
Hexokinas
Phosphohexose isomerase
Phosphoglycerate kinase
Pyruvate kinase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Transfer of glucose to cell

A

Hexose monophosphate shunt or g6pd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Enzyme involve in methemoglobin

A

Glutathione synthetase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are wxtrinsic that cause HA

A 
Acquired autoimmune HA
PCH
Infection
Drugs
Chemicals
Mechanical
Physical agents
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Under chemicals

A

Benzene
Aniline
Lead

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Acquired autoimmune HA

A

Blood transfusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Mechanical

A

Externous exercise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Ass with exposure to cold temperature due to the presence of cold agglutinin ab called

A

Donath landsteiner hemolysin/ pch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Colored of urine sa,ple of PCH

A

Tea sampled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Ass with complement mediated hemolysis

A

PNH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Due to a ded of activity of acetyl cholinesterase that is found in the cell membrane

A

PNH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Due to the presence of HbA variant causes sickling of RBC under reduce oxygen tension

A

Sickle cell anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Inclusion bodies of SIckle cell anemia

A

Howell jolly and cabots ring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Sickle cell causes

A

Vaso occlusive crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Blood picture of sickle cell anemia

A 
Normocytic normochromic
Sickle cell
Thrombocytosis
Neutrophilia
Anistocytosis
Poikilocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

OFI of sickle cell

A

Dec

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Presence of 2 HbS

A

Homozygous SC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Carrier they have the sickle cell trait

A

Heterozygous sc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Simple test for sickle cell anemia

A

Scribr and waugh method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Normal 2 aloha and 2 beta chain

A

HbA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Method becsuse it uses deoxygenizers

A

Daland and Dasilva

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Sample of deoxygenizer

A

2% ascorbic acid, 2% na metabisulfite, 2% na dithionite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Uses formol saline solution

A

Shermans method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

To seal and prevent the entrance of oxygen

A

Mineral oil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Comoutation in sickle cell anemia

A

of sc/100x100

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

40% is observed after an hr in Sc has

A

Sickle cell anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

1% of SC after an hour

A

Sickle cell trait

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Due to abnormal production rate pf the one of the polypeptide chain of hb molecule. It can be alpha or beta

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Other name of thalassemia

A

Cooleys anemia, mediterranean anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Predominant cell of target cell

A

Hereditary leptocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Common in southeast asia

A

Alpha and beta thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Indices of thalassemia

A

Microcytic hypochromic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Inclusion bodies of thalassemia

A

Howell jolly bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Blood picture

A

Poikilo
Anisto
Inc nucleated nrbc
Hepatosplenomegaly jaundice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

OFI of thalassemia

A

Decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Inclusion bodies of beta thalassemia

A

Heinz and howell jolly bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Cause by point mutation that results in premature chain termination or abnormal transcription of rna that leads to formation of reduce/absence of b globin chain

A

Beta thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Predominance od hbF

A

Beta thalassemia major

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

2 alpha 2 gamma

A

HbF

57
Q

Predominance of hbA2

A

B thalassemia minor

58
Q

2 alpha 2 delta

A

HbA2

59
Q

Due to the gene dletion causing reduce a globulin chain synthesis and in severe form fprm there will be an excess beta chain that leads of the formation of b tetramer characterized by beta

A

Alpha thalassemia

60
Q

Hgb variant that contains 4 beta chain

A

HbH

61
Q

Presence of what due to reduce form of alpha

A

HbH

62
Q

4 gamma chain

A

Barts hb

63
Q

For,ed due to the fuctional inability if the B, to replace rbc

A

Apastic anemia

64
Q

Results from either a dec or absence in beta chain production by both allele gene

A

Thalassemia major or homozygous beta thalassemia

65
Q

Dec in beta chain production, gamma chain production is high which resukt in increased HbF

A

Thalassemia major, homozygous beta thalassemia

66
Q

Excess of alpha chain due to lack of matching beta chain

A

Thalassemia major p, homozygous beta thalassemia

67
Q

Major cause of death in beta thalassemia major

A

Cardiac failure

68
Q

Indirect bilirubin in beta thalassemia major

A

Dec

69
Q

Mcv and rdw in beta thalassemia major

A

Dec and inc

70
Q

OFI of thalassemia

A

Dec

71
Q

What would be expected because of destruction of erythroid precursor in the marrow

A

Retics ct is elevated

72
Q

Result from the absence or dec in beta chain production of one allele gene

A

Thalassemia minor heterozygous beta thalassemia

73
Q

Resufrom severe microcytic hypochromic anemia to what

A

Normal clinical finding which is thalassemia minor

74
Q

Rbc ct in thalassemia minor

A

Inc

75
Q

Hb and hct in thalassemia minor

A

Reduced

76
Q

Rdw in thalassemia minor is

A

Inc

77
Q

Extreme poikilo and anistocytosis and thalassemia major

A

Target cell, ovalocytes, hjb, normoblasts,siderocytes, cabot ring

78
Q

Smear show what moderate poikilo in beta thalassemia minor

A

Target cell, basophilic stip

79
Q

Thalassemia minor serum iron level

A

Normal to inc

80
Q

OFI beta thalassemia minor

A

Dec

81
Q

Resukts from a partial or total decrease in the production of alpha chain

A

Alpha thalassemia

82
Q

Is deletion of only one gene

A

Mild aloha thalassemia

83
Q

Deletion of two alpha globin gene

A

Severe alpha thalassemia

84
Q

Most severe form of alpha thalassemia

A

Hydrops fetalis wuth Hb barts

85
Q

Ansence of alpha chains 4 gamma chains

A

Hydrops fetalis with hb barts

86
Q

Thalassemia in which three of the four alpha globin genes are absent –/-a

A

HbH dse, alpha thalassemia major

87
Q

Patientwhi have this have a chronic HA

A

HbH alpha thalassemia major

88
Q

Mcv and mch in alpha thalassemia major are

A

Dec

89
Q

Due to depletion of iron storage in the body needed for hemoglobin production

A

Severe iron def anemia

90
Q

Iron absorp by

A

Duodenum

91
Q

Vitb12 absorp by

A

Ileum

92
Q

Folate absorp by

A

Jejunum

93
Q

Absence of hcl and gastric acid

A

Achlorydria

94
Q

Severe IDA causes

A

Due to poor diet
Due to faulty absorption
Excessive iron loss
Iron excessive demand

95
Q

Indices of IDA

A

Microcytic hypochromic

96
Q

OFI in severe IDA

A

Dec

97
Q

Blood picture of severe IDA

A

Anisto
Poikilo
Thrombocytosis

98
Q

Is a conditioned nutritional def of b12

A

Pernicious anemia

99
Q

PA also called

A

Macrocytic or megalocytic anemia or addisonians anemia

100
Q

Due to lack of instrinsic factor needed

A

Absorption of B12/folic acid

101
Q

Increase form of wbc specifically what rbc

A

Shift to the right hypersegmented neutrophils

102
Q

Indices of pernicious anemia

A

Macrocytic hypochromic

103
Q

Blood picture of PA

A

Leukopenia, thrombocytopenia, pancytopenia anisto, poikilo

104
Q

Inclusion bodies of PA

A

Howell jolly bodies cabots ring

105
Q

Most commonly occu as a result of an iron deficiency but can result from a block in the enzyme that inserts iron into heme ring

A

Iron metabolism disorder

106
Q

It is a non functioning without iron and two thirs or more of the tital bidy iron is in the rbc and their precursors

A

Hb molecule

107
Q

Each milliliter of rbc contain

A

1mg of iron

108
Q

Storage iron is present in as what

A

Macrophage and normoblast as ferritin or hemosiderin

109
Q

It is tranportee to normoblast gu plasma transferrin

A

Recycled Hb

110
Q

Only lost of the iron from the body per day

A

0.9-1.3 mg

111
Q

Result when iron loss extends iron intake for a long time and the body’s iron stores are depleted

A

IDA

112
Q

Develops when there is excessive chronic loss of blood

A

IDA

113
Q

Develops when increas need for iron such as rapid growth in infancy childhood and pregnancy

A

IDA

114
Q

Beginning of iron deficiency a negative balance develops and iron mobilized from iron stores when turns process storage iron and plasma ferritin DEC. gi absorption and tibc is INC

A

Iron depletion stage

115
Q

Occurs when tissue iron are depleted when transformed saruration falls the percent if marrow sideroblast dec and serum iron dec and level of photoporohyrin inc

A

Iron def erythropoiesis stage

116
Q

A clinical anemia become detectable as normocytic normochromic then graduallt to a macrocytic hypochromic anemia

A

By the ida stage

117
Q

Condition of iron excess from a abnormality gene on chrom 6

A

Primary familial hemachromatosis

118
Q

Inc absorption by intestinal mucosal cell

A

Primary familial hemachromatosis

119
Q

Inc serum level, transferrin saturation and iron loading macrophage and hepatocyte

A

Primary familial hemachromatosis

120
Q

Disprdr of iroj excess that is ass with defective synthesis of heme becsuse of multiple enzyme defects and resuting a iron overload in the mitochondria of normoblast

A

Sideroblastic anemia

121
Q

Inc serum level, transferrin, sideroblastic and dec tibc

A

Sideroblastic anemia

122
Q

Refers to the amount of iron that could be bound by saturating transferrin and ither minor iron binding proteins present in serum or plasma sample

A

Tibc

123
Q

Anemia of chronic infection has

A

Low or normal tibc

124
Q

Ida has

A

Hight tibc

125
Q

Non iron anemia has

A

Has low tibc

126
Q

Excess iron removed by adding what to measure bound iron

A

Mg carbonate to

127
Q

Rv of tibc in adult

A

245-425mg dl

128
Q

Rv of tibc in 40yo

A

10-250ug/dl

129
Q

Rv of tibc in newborn

A

100-200ug/dl

130
Q

For,ula of tibc

A

Uibc + serum iron

131
Q

Tibc increased in

A

Ida hepatistis and iron supplemented preg

132
Q

Tibc dec in non ida and nephrosis

A

Decreased

133
Q

A measure of the reserbed iron binding capacity of transferrin

A

UIBC

134
Q

Formula of uibc

A

Tubc - serum iron

135
Q

It is known as transferrin saturation or index of iron storage

A

Percent saturation

136
Q

Ratio of serum iron to tibc

A

Percent saturation

137
Q

Percent saturation inc in

A

Iron overdose hema, SA

138
Q

Percent saturation dec

A

in ida, malignancy , chronic infection p, anemia of chronic dse

139
Q

Percent saturation rv

A

20-50%

Hema 2 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions