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Leukemia Flashcards

1
Q

Causes of leukemia

A

Epidemiology
Viruses
Genetics
Radiation

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2
Q

Classification of leukemia

A 
Accdg to duration of dse
Accdg to no of wbc
Accdg to wbc specific type
Accdg to age
Fab classification
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3
Q

Survival rate of the patient

A

Accdg to duration of dse

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4
Q

High percentage of young forms or blast cells

A

Acute leukemia

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5
Q

Survival rate of acyte leukemia

A

Days to 6 months

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6
Q

Acute leukemia is characterized by the ff

A 
Sudden onset of dse
Rapidly developing anemia
High fever
Thrombocytopenia
Hemorrhages
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7
Q

Characterized by the presence of slightly differentiated cells

A

Subacute leukemia

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8
Q

Survival rate of subacute leukemia

A

6-1yr

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9
Q

Characterized bu predominance of old forms

A

Chronic leukemia

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10
Q

Fatal systemic dse characterized by an excessive proloferation of wbc producing cells such that cell show a different degree of immaturity so therefore this is considered malignant growth of cells

A

Leukemia

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11
Q

Survival rate of chronic leukemia

A

1yr to several years

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12
Q

Chronic leukemia is characterized by what

A

Gradual onset
General body weakness
East fatigability
Bones that is tender to pressure due to leukemic reaction

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13
Q

What are accdg to wbc specific type

A

Acute monocyticleukemia and chronic monocyticleukemia

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14
Q

Predominance of monocytic myeloblast

A

Acute monocyticleukemia

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15
Q

Predominance of pld and mature monocyte

A

Chronic monocytic leukemia

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16
Q

Chronic monocytic leukemia categorized as

A

Nageli and schillings

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17
Q

Resembles granulocytic leukemia due to the presence of myeloid cells

A

Naegli type monocytic leukemia or M4

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18
Q

True monocyticleukemia

A

Schillings type

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19
Q

Accdg to number of wbc

A

Leukemic leukemia
Subleukemic leukemia
Aleukemic leukemia

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20
Q

Predominance of blast cells wbc ct of more than 15,000mm3

A

Leukemic leukemia

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21
Q

Predominance of the old form dec 15,000mm3

A

Aleukemic leukemia

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22
Q

Slightly differentiated cells dec wbc ct 15,000mm3

A

Subleukemic leukemia

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23
Q

Predominance of eos, baso, and neutrophil. Characterized by presence of philadelphia chromosome 22

A

Chronic myelocytic leukemia

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24
Q

Predominance of young forms rbc

A

Erythremicmyelosis di gugliemos disease

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25
Q

Combination of blast cell of the rbc and the wbc

A

Erythroleukemia di guglielmo’s syndrome

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26
Q

Predominace of blast cells

A

Blast cell leukemia or stem cell leukemia

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27
Q

Predominance of young lymphocytes

A

Acute lymphocytic leukemia

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28
Q

Predominance of old and mature lymphocyte

A

Chronic lymphocytic leukemia

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29
Q

Predominated pf progranulocyte

A

Pro granulocytic leukemia

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30
Q

Predominance of neutrophilic myelocyte

A

Neutrophilic leukemia

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31
Q

Predominance od eosinophilic myelocyte

A

Eosinophilic leukemia

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32
Q

Predominance of basophilic myelocyte

A

Basophilic leukemia

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33
Q

Predominance in a dse called myeloma,ntumor involving bone marrow and other organ

A

Plasmacytic leukemia

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34
Q

Predominance of plasma cell but this leukemia found in the terminal stage of muktiple myeloma

A

Plasma cell leukemia

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35
Q

Rarest form of leukemia, said to be tissue basophil

A

Mast cell leukemia

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36
Q

What are accdg to age

A

Acute leukemia
Chronic lymphocytic leukemia
Chronic granulocytic

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37
Q

20-50yp

A

Chronic granulocytic

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38
Q

Less than 20 yo

A

Acute leukemia

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39
Q

More than 50 yo

A

Chronic lymphocytic leukemia

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40
Q

It divudes acute leukemias into lymphoblastic and monoblastic

A

fab classification

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41
Q

Two main groups are subdivided accd to cellular morphology, cytochemical staining results, cytogenetic studies T and B lymohocye marker result

A

Fab classificiation

42
Q

Childhoold ALL. Lymphoblast are small and homogenous with a very high nucleus and cytoplasm ratio

A

L1 classification

43
Q

Adult ALL lymphoblast are larger and has a variable size nucleus is clefted and will observed with presence of nucleoli

A

L2 classification

44
Q

Least case among three ALL, Accounts 2% in all cases

45
Q

Acute myeloblastic leukemia

46
Q

Acute megakryocytic leukemia

47
Q

Acute myelomonocyctic leukemia

48
Q

Acute monocytic leukemia

49
Q

Acute promyelocytic leukemia

50
Q

Acute myeloblastic leukemia without maturation

51
Q

Acute promyelocyticleukemia

52
Q

Acute myeloblastic leukemia with maturation

53
Q

Acute monoblastic leukemia without maturation

54
Q

Acute myelomonocytic leukemia

55
Q

Di guglielmos syndrome erythroleukemia, erythremicmyelosis

56
Q

Acute monoblastic leukemia with maturation

57
Q

Acute megakaryocytic leukemia

58
Q

Undifferentiated blast no maturation

A

Mo minimally differentiated

59
Q

Scanty cytoplasm

A

M1 aml without maturation

60
Q

Myeloid phenotype of m1

A

Cd13,33,117

61
Q

Myeloid phenotype of m2

62
Q

Kidney shape nucleus

A

M2 aml with maturation

63
Q

Promyelocyte predominant

A

M3 hypergranular promyelocyte

64
Q

Negative auer rods and esterase

A

Mo minimally differentiated

65
Q

Myeloid ohenotype of mo

A

Cd13,33,34

66
Q

Arge cell round nucleus

A

M1 aml without maturation

67
Q

Common type

A

M2 aml woth maturation

68
Q

High serum lysozyme level

A

M4 acute myelomonocytic

69
Q

High incidence of DIC

A

M3 hypergranular promyelocyte

70
Q

Acute myeloid leukemia with very abnormal cell

A

M3 hypergranular promyelocyte

71
Q

Myeloid phenotype of m3

72
Q

Eosinophilic granules

A

M2 aml with maturation

73
Q

> 3% pos mpo and sbb

A

M1 aml wo maturation

74
Q

Positive for auer rods

A

M2 aml with maturation

75
Q

More than 50% pos mpo and sbb

A

M2 aml with maturation

76
Q

Basophilic bilobed nuclei

A

M3 hypergranular promyelocyte

77
Q

Pos for auer rods or faggot cells

A

M3 hypergranular promyelocyte

78
Q

Large kidney shape

A

M3 hypergranular promyelocyte

79
Q

Monoblast few promonocyte

A

M5a without maturation

80
Q

Myeloid ohenotype of m4

A

Cd 11,13,14,33

81
Q

Positive in common auer rods

A

M4 acute myelomonocytic

82
Q

Blast, promonocyte bone marrow and monocyte in blood

A

M5b with maturation

83
Q

Monocyte ameloid with round to oval nuclei

84
Q

Prominent nuclei

85
Q

Large bizarre round to oval cells

A

M6 erythroleukemia

86
Q

Dec in 20% promonocyte and monocyte

87
Q

Promonocyte, foldedm convoluted nucleus

88
Q

Inc in 20% monocyte

89
Q

Pos in PAS

A

M6 erythroleukemia

90
Q

Posituve in nucleoli

A

M6 erythroleukemia

91
Q

Myeloid phenotype of glycophorin A in m6

92
Q

Myeloid phenotype myeloblast in m6

A

Cd 13,15,33

93
Q

More than 50% erythroblast

94
Q

More than 30% myeloblast

95
Q

More than 30% megakaryoblast

A

M7 acute megakaryoblastic

96
Q

Platelet like granules in Pas stain

A

M7 acute megakaryoblastic

97
Q

Myeloid blast may show sbb or mpo pos

A

M7 acute megakartyoblastic

98
Q

Myeloid phenotype of m7

A

Cd41,42,61

99
Q

More than 30% myeloblast

100
Q

More than 30% of myeloblast 20% granulocyte ahd 20% promonocyte abd monocyte

101
Q

More than 30% myeloblast 10% granulocyte

A

M2 aml with maturation

Hema 2 (10 decks)

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